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Ccdc154 coiled-coil domain containing 154 [ Mus musculus (house mouse) ]

Gene ID: 207209, updated on 9-Dec-2024

Summary

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Official Symbol
Ccdc154provided by MGI
Official Full Name
coiled-coil domain containing 154provided by MGI
Primary source
MGI:MGI:2685163
See related
Ensembl:ENSMUSG00000059562 AllianceGenome:MGI:2685163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ntl; Gm317; Ccdc157
Summary
Acts upstream of or within several processes, including bone mineralization involved in bone maturation; bone resorption; and odontogenesis. Predicted to be located in early endosome. Used to study autosomal recessive osteopetrosis 1. Orthologous to human CCDC154 (coiled-coil domain containing 154). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 10.0), stomach adult (RPKM 1.3) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Ccdc154 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25381142..25390887)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25162175..25171913)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene pentraxin 4 Neighboring gene chloride channel, voltage-sensitive 7 Neighboring gene microRNA 12188 Neighboring gene intestine-critical region regulatory element Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25321285-25321526 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene predicted gene, 52286 Neighboring gene unkempt family like zinc finger

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CCDC154 Mutant Caused Abnormal Remodeling of the Otic Capsule and Hearing Loss in Mice. Xu K, et al. Front Cell Dev Biol, 2021. PMID 33614666, Free PMC Article
  2. Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest. Liao W, et al. Cell Cycle, 2012 Sep 1. PMID 22895184, Free PMC Article
  3. A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots. Lu X, et al. Eur J Oral Sci, 2009 Dec. PMID 20121924, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in bone mineralization involved in bone maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone mineralization involved in bone maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tooth eruption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 154
Names
Grailexp predicted
golgin-160-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079929.2 → NP_001073398.2  coiled-coil domain-containing protein 154

    See identical proteins and their annotated locations for NP_001073398.2

    Status: VALIDATED

    Source sequence(s)
    AK133084, JN935900
    Consensus CDS
    CCDS50032.2
    UniProtKB/Swiss-Prot
    G9JV17, Q3V0K0, Q6RUT8
    UniProtKB/TrEMBL
    S4R1F0
    Related
    ENSMUSP00000138090.2, ENSMUST00000182621.8
    Conserved Domains (1) summary
    pfam15450
    Location:48 → 573
    CCDC154; Coiled-coil domain-containing protein 154

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25381142..25390887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523949.4 → XP_006524012.1  coiled-coil domain-containing protein 154 isoform X1

    UniProtKB/TrEMBL
    S4R1F0
    Conserved Domains (1) summary
    pfam15450
    Location:48 → 574
    CCDC154; Coiled-coil domain-containing protein 154

  2. XM_006523951.4 → XP_006524014.1  coiled-coil domain-containing protein 154 isoform X2

    UniProtKB/TrEMBL
    S4R1F0
    Conserved Domains (1) summary
    pfam15450
    Location:48 → 485
    CCDC154; Coiled-coil domain-containing protein 154

  3. XM_006523952.4 → XP_006524015.1  coiled-coil domain-containing protein 154 isoform X3

    Conserved Domains (1) summary
    pfam15450
    Location:48 → 430
    CCDC154; Coiled-coil domain-containing protein 154

  4. XM_006523954.4 → XP_006524017.1  coiled-coil domain-containing protein 154 isoform X5

    Conserved Domains (1) summary
    pfam15450
    Location:48 → 429
    CCDC154; Coiled-coil domain-containing protein 154

  5. XM_006523955.4 → XP_006524018.1  coiled-coil domain-containing protein 154 isoform X6

    Conserved Domains (1) summary
    pfam15450
    Location:48 → 431
    CCDC154; Coiled-coil domain-containing protein 154

  6. XM_006523953.1 → XP_006524016.1  coiled-coil domain-containing protein 154 isoform X4

    Conserved Domains (1) summary
    pfam15450
    Location:1 → 352
    CCDC154; Coiled-coil domain-containing protein 154

RNA

  1. XR_385305.4 RNA Sequence

  2. XR_385306.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RUT8.3 GenPept UniProtKB/Swiss-Prot:Q6RUT8

Gene LinkOut

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