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Serpinb9d serine (or cysteine) peptidase inhibitor, clade B, member 9d [ Mus musculus (house mouse) ]

Gene ID: 20726, updated on 4-Jan-2025

Summary

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Official Symbol
Serpinb9dprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 9dprovided by MGI
Primary source
MGI:MGI:894667
See related
Ensembl:ENSMUSG00000054266 AllianceGenome:MGI:894667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AT2; Spi9; ovalbumin
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protease binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of endopeptidase activity; and protection from natural killer cell mediated cytotoxicity. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and extracellular space. Orthologous to human SERPINB9 (serpin family B member 9). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward placenta adult (RPKM 22.5) See more
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Genomic context

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See Serpinb9d in Genome Data Viewer
Location:
13 A3.3; 13 13.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33376938..33387964)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33192955..33203981)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34117 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9c Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9e Neighboring gene predicted gene, 40905

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). Sun J, et al. J Biol Chem, 1997 Jun 13. PMID 9182575
  2. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365
  3. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protection from natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine (or cysteine) proteinase inhibitor, clade B, member 9d
Names
serine protease inhibitor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011460.3 → NP_035590.1  serine (or cysteine) proteinase inhibitor, clade B, member 9d

    See identical proteins and their annotated locations for NP_035590.1

    Status: VALIDATED

    Source sequence(s)
    AK028382, AL645704, D19505
    Consensus CDS
    CCDS26434.1
    UniProtKB/TrEMBL
    Q80Y29, Q8BMT0
    Related
    ENSMUSP00000067710.3, ENSMUST00000067198.3
    Conserved Domains (1) summary
    cl38926
    Location:1 → 377
    serpin; SERine Proteinase INhibitors (serpin) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    33376938..33387964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516630.3 → XP_006516693.1  serine (or cysteine) proteinase inhibitor, clade B, member 9d isoform X1

    See identical proteins and their annotated locations for XP_006516693.1

    UniProtKB/TrEMBL
    Q80Y29, Q8BMT0
    Conserved Domains (1) summary
    cl38926
    Location:1 → 377
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version

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