Baiap2l2 BAI1-associated protein 2-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Baiap2l2provided by MGI
Official Full Name: BAI1-associated protein 2-like 2provided by MGI
Primary source: MGI:MGI:2652819
See related: Ensembl:ENSMUSG00000018126 AllianceGenome:MGI:2652819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables identical protein binding activity and phospholipid binding activity. Involved in membrane organization. Predicted to be located in cell-cell contact zone and vesicle membrane. Predicted to be part of clathrin complex. Predicted to be active in cytosol and nucleoplasm. Is expressed in brain. Orthologous to human BAIAP2L2 (BAR/IMD domain containing adaptor protein 2 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 107.8), small intestine adult (RPKM 66.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79142395..79169756, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79258195..79285556, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology.
Title: BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology.
HNF1beta-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
Title: HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
Ca(2+) entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.
Title: Ca(2+) entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.
BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells.
Title: BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells.
Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.
Title: Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.
Pinkbar, is specifically expressed in intestinal epithelial cells, where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions.
Title: Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237347

D15Mit238 (e-PCR), detects polymorphism
- UniSTS:127610

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISS Inferred from Sequence or Structural Similarity more info
part_of clathrin complex	IEA Inferred from Electronic Annotation more info
part_of clathrin complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: BAR/IMD domain-containing adapter protein 2-like 2; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Names: BAI1-associated protein 2-like protein 2; pinkbar; planar intestinal- and kidney-specific BAR domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177580.3 → NP_808248.1 BAR/IMD domain-containing adapter protein 2-like 2

See identical proteins and their annotated locations for NP_808248.1

Status: VALIDATED

Source sequence(s)

AL591913

Consensus CDS

CCDS37140.1

UniProtKB/Swiss-Prot

Q3UP58, Q80Y61

Related

ENSMUSP00000127816.2, ENSMUST00000165408.8

Conserved Domains (2) summary

cd07644
Location:6 → 220

I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

cd11914
Location:327 → 385

SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79142395..79169756 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520679.2 → XP_006520742.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X1

Conserved Domains (2) summary

cd07644
Location:6 → 220

I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

cd11914
Location:327 → 385

SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
XM_006520682.4 → XP_006520745.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

See identical proteins and their annotated locations for XP_006520745.1

Conserved Domains (1) summary

cd11914
Location:120 → 178

SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
XM_006520680.5 → XP_006520743.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

See identical proteins and their annotated locations for XP_006520743.1

Conserved Domains (1) summary

cd11914
Location:120 → 178

SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
XM_030248434.1 → XP_030104294.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X2

Conserved Domains (2) summary

PRK12323
Location:116 → 231

PRK12323; DNA polymerase III subunit gamma/tau

cl17036
Location:251 → 309

SH3; Src Homology 3 domain superfamily
XM_006520681.3 → XP_006520744.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

See identical proteins and their annotated locations for XP_006520744.1

Conserved Domains (1) summary

cd11914
Location:120 → 178

SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2