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Ssr4 signal sequence receptor, delta [ Mus musculus (house mouse) ]

Gene ID: 20832, updated on 27-Nov-2024

Summary

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Official Symbol
Ssr4provided by MGI
Official Full Name
signal sequence receptor, deltaprovided by MGI
Primary source
MGI:MGI:1099464
See related
Ensembl:ENSMUSG00000002014 AllianceGenome:MGI:1099464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trap; SSR-delta; TRAP-delta
Summary
Predicted to be located in endoplasmic reticulum. Predicted to be part of Sec61 translocon complex. Predicted to be active in endomembrane system. Is expressed in several structures, including gut; jaw; musculoskeletal system; nasal capsule; and submandibular gland primordium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iy. Orthologous to human SSR4 (signal sequence receptor subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 108.4), duodenum adult (RPKM 90.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ssr4 in Genome Data Viewer
Location:
X A7.3; X 37.41 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72830778..72834432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73787023..73790828)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich protein specific kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E11049 Neighboring gene isocitrate dehydrogenase 3 (NAD+), gamma Neighboring gene STARR-seq mESC enhancer starr_47355 Neighboring gene PDZ domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_47357 Neighboring gene predicted gene, 23615 Neighboring gene STARR-seq mESC enhancer starr_47358 Neighboring gene STARR-seq mESC enhancer starr_47359 Neighboring gene L1 cell adhesion molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary. Holthuis JC, et al. Biochem J, 1995 Nov 15. PMID 7492314, Free PMC Article
  2. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Brenner V, et al. Genomics, 1997 Aug 15. PMID 9286695
  3. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Nguyen TD, et al. Blood, 2019 Jan 10. PMID 30498063
  4. Hepatic lipase maturation: a partial proteome of interacting factors. Doolittle MH, et al. J Lipid Res, 2009 Jun. PMID 19136429, Free PMC Article
  5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
translocon-associated protein subunit delta
Names
signal sequence receptor subunit delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166480.3 → NP_001159952.1  translocon-associated protein subunit delta isoform 1 precursor

    See identical proteins and their annotated locations for NP_001159952.1

    Status: VALIDATED

    Source sequence(s)
    AL672094
    Consensus CDS
    CCDS53099.1
    UniProtKB/TrEMBL
    Q9D8L3, Q9DC94
    Related
    ENSMUSP00000131386.2, ENSMUST00000166518.8
    Conserved Domains (1) summary
    pfam05404
    Location:22 → 172
    TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

  2. NM_001358212.2 → NP_001345141.1  translocon-associated protein subunit delta isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672094
    Conserved Domains (1) summary
    pfam05404
    Location:22 → 117
    TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

  3. NM_001358213.2 → NP_001345142.1  translocon-associated protein subunit delta isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672094
    Conserved Domains (1) summary
    pfam05404
    Location:1 → 109
    TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

  4. NM_001426003.1 → NP_001412932.1  translocon-associated protein subunit delta isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672094

  5. NM_001426004.1 → NP_001412933.1  translocon-associated protein subunit delta isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672094

  6. NM_009279.5 → NP_033305.1  translocon-associated protein subunit delta isoform 2 precursor

    See identical proteins and their annotated locations for NP_033305.1

    Status: VALIDATED

    Source sequence(s)
    AL672094
    Consensus CDS
    CCDS30213.1
    UniProtKB/Swiss-Prot
    Q62186
    UniProtKB/TrEMBL
    Q3TVJ8, Q9D6F7
    Related
    ENSMUSP00000002090.3, ENSMUST00000002090.3
    Conserved Domains (1) summary
    pfam05404
    Location:22 → 171
    TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72830778..72834432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62186.1 GenPept UniProtKB/Swiss-Prot:Q62186

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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