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Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20859, updated on 27-Nov-2024

Summary

Official Symbol
Sult2a1provided by MGI
Official Full Name
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1provided by MGI
Primary source
MGI:MGI:98430
See related
Ensembl:ENSMUSG00000078798 AllianceGenome:MGI:98430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Std; Sth1; ST2A1; mSTa1
Summary
Enables alcohol sulfotransferase activity and steroid sulfotransferase activity. Involved in steroid metabolic process. Acts upstream of or within sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; facial prominence; hemolymphoid system gland; and reproductive system. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver adult (RPKM 20.9) See more
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Genomic context

See Sult2a1 in Genome Data Viewer
Location:
7 A1; 7 8.02 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13530171..13571335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13796246..13837410, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 167, pseudogene 1 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 Neighboring gene STARR-seq mESC enhancer starr_18085 Neighboring gene zinc finger, BED type containing 4, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_18086 Neighboring gene k(lysine) acetyltransferase 6B, pseudogene 2 Neighboring gene transmembrane protein 167, pseudogene 2 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables alcohol sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alcohol sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables bile-salt sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables bile-salt sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ethanol catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sulfation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in sulfation ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sulfotransferase 2A1
Names
ST
bile salt sulfotransferase 1
hydroxysteroid sulfotransferase
sulfotransferase, DHEA preferring
sulfotransferase, hydroxysteroid preferring 1
NP_001104766.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111296.2NP_001104766.1  sulfotransferase 2A1

    See identical proteins and their annotated locations for NP_001104766.1

    Status: VALIDATED

    Source sequence(s)
    AC157361
    Consensus CDS
    CCDS52031.1
    UniProtKB/Swiss-Prot
    P50236, P52843, Q05A88
    Related
    ENSMUSP00000104162.4, ENSMUST00000108522.5
    Conserved Domains (1) summary
    pfam00685
    Location:34278
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    13530171..13571335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)