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Thnsl1 threonine synthase-like 1 (bacterial) [ Mus musculus (house mouse) ]

Gene ID: 208967, updated on 27-Nov-2024

Summary

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Official Symbol
Thnsl1provided by MGI
Official Full Name
threonine synthase-like 1 (bacterial)provided by MGI
Primary source
MGI:MGI:2139347
See related
Ensembl:ENSMUSG00000048550 AllianceGenome:MGI:2139347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human THNSL1 (threonine synthase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 5.4), CNS E18 (RPKM 4.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Thnsl1 in Genome Data Viewer
Location:
2 A3; 2 14.83 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (21210236..21232948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (21205425..21228134)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphoribosyltransferase domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03890 Neighboring gene STARR-seq mESC enhancer starr_03891 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1240 Neighboring gene STARR-seq mESC enhancer starr_03892 Neighboring gene PHD finger protein 3 pseudogene Neighboring gene predicted gene, 54105

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
threonine synthase-like 1
Names
TSH1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001297.2 → NP_001001297.1  threonine synthase-like 1 isoform b

    See identical proteins and their annotated locations for NP_001001297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AK029518, AK033465, AK083895
    Consensus CDS
    CCDS15721.1
    UniProtKB/TrEMBL
    A2AUG7
    Related
    ENSMUSP00000100017.2, ENSMUST00000102952.8
    Conserved Domains (1) summary
    cl00342
    Location:1 → 212
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

  2. NM_001362772.1 → NP_001349701.1  threonine synthase-like 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AL929117, BB664224
    Consensus CDS
    CCDS15721.1
    UniProtKB/TrEMBL
    A2AUG7
    Related
    ENSMUSP00000100016.2, ENSMUST00000102951.2
    Conserved Domains (1) summary
    cl00342
    Location:1 → 212
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

  3. NM_001362773.1 → NP_001349702.1  threonine synthase-like 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AL929117, BQ551065
    Consensus CDS
    CCDS15721.1
    UniProtKB/TrEMBL
    A2AUG7
    Conserved Domains (1) summary
    cl00342
    Location:1 → 212
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

  4. NM_177588.2 → NP_808256.1  threonine synthase-like 1 isoform a

    See identical proteins and their annotated locations for NP_808256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK029518, AK083895
    Consensus CDS
    CCDS15720.1
    UniProtKB/Swiss-Prot
    Q8BH55
    UniProtKB/TrEMBL
    Q149D1
    Related
    ENSMUSP00000052452.4, ENSMUST00000054591.10
    Conserved Domains (2) summary
    cd01560
    Location:230 → 733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    pfam01202
    Location:64 → 221
    SKI; Shikimate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    21210236..21232948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497433.4 → XP_006497496.1  threonine synthase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006497496.1

    UniProtKB/Swiss-Prot
    Q8BH55
    UniProtKB/TrEMBL
    Q149D1
    Conserved Domains (2) summary
    cd01560
    Location:230 → 733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    pfam01202
    Location:64 → 221
    SKI; Shikimate kinase

  2. XM_006497431.5 → XP_006497494.1  threonine synthase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006497494.1

    UniProtKB/Swiss-Prot
    Q8BH55
    UniProtKB/TrEMBL
    Q149D1
    Conserved Domains (2) summary
    cd01560
    Location:230 → 733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    pfam01202
    Location:64 → 221
    SKI; Shikimate kinase

  3. XM_006497432.5 → XP_006497495.1  threonine synthase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006497495.1

    UniProtKB/Swiss-Prot
    Q8BH55
    UniProtKB/TrEMBL
    Q149D1
    Conserved Domains (2) summary
    cd01560
    Location:230 → 733
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    pfam01202
    Location:64 → 221
    SKI; Shikimate kinase

  4. XM_030249108.2 → XP_030104968.1  threonine synthase-like 1 isoform X2

    UniProtKB/TrEMBL
    A2AUG7
    Conserved Domains (1) summary
    cl00342
    Location:1 → 212
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH55.1 GenPept UniProtKB/Swiss-Prot:Q8BH55

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