U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Med22 mediator complex subunit 22 [ Mus musculus (house mouse) ]

Gene ID: 20933, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Med22provided by MGI
Official Full Name
mediator complex subunit 22provided by MGI
Primary source
MGI:MGI:98446
See related
Ensembl:ENSMUSG00000015776 AllianceGenome:MGI:98446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Surf5; Surf-5
Summary
Predicted to enable transcription coregulator activity. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in embryo; tibialis anterior; and tongue. Orthologous to human MED22 (mediator complex subunit 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 19.6), ovary adult (RPKM 17.4) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Med22 in Genome Data Viewer
Location:
2 A3; 2 19.09 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26795279..26800654, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26905267..26910642, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Neighboring gene STARR-seq mESC enhancer starr_03995 Neighboring gene STARR-seq mESC enhancer starr_03996 Neighboring gene surfeit gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26758332-26758621 Neighboring gene predicted gene, 23969 Neighboring gene predicted gene, 22879 Neighboring gene ribosomal protein L7A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. Angiolillo A, et al. Gene, 2002 Feb 6. PMID 11891058
  2. Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death. Rodriguez PQ, et al. Sci Rep, 2020 Nov 18. PMID 33208756, Free PMC Article
  3. The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA. Huxley C, et al. Mol Cell Biol, 1990 Feb. PMID 2300057, Free PMC Article
  4. Primary structure and characterization of an androgen-stimulated autoantigen purified from mouse seminal-vesicle secretion. Yu LC, et al. Biochem J, 1993 Dec 15. PMID 8280054, Free PMC Article
  5. Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene. Garson K, et al. Genomics, 1995 Nov 20. PMID 8586415

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death.
    Title: Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mediator of RNA polymerase II transcription subunit 22
Names
surfeit gene 5
surfeit locus protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033908.1 → NP_001029080.1  mediator of RNA polymerase II transcription subunit 22 isoform 2

    See identical proteins and their annotated locations for NP_001029080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the coding region, compared to variant 1. The resulting isoform (2) is longer and has a unique C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL773563, BG805496
    Consensus CDS
    CCDS15813.1
    UniProtKB/Swiss-Prot
    A2ALA2, Q3TTZ9, Q62276
    Related
    ENSMUSP00000015920.6, ENSMUST00000015920.12
    Conserved Domains (1) summary
    pfam06179
    Location:20 → 124
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

  2. NM_001378786.1 → NP_001365715.1  mediator of RNA polymerase II transcription subunit 22 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Conserved Domains (1) summary
    pfam06179
    Location:20 → 160
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

  3. NM_001378787.1 → NP_001365716.1  mediator of RNA polymerase II transcription subunit 22 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Conserved Domains (1) summary
    pfam06179
    Location:1 → 64
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

  4. NM_001378788.1 → NP_001365717.1  mediator of RNA polymerase II transcription subunit 22 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Conserved Domains (1) summary
    pfam06179
    Location:20 → 97
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

  5. NM_011513.2 → NP_035643.1  mediator of RNA polymerase II transcription subunit 22 isoform 1

    See identical proteins and their annotated locations for NP_035643.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the shorter protein (isoform 1).
    Source sequence(s)
    AL773563
    Consensus CDS
    CCDS15814.1
    UniProtKB/Swiss-Prot
    Q62276
    Related
    ENSMUSP00000099963.4, ENSMUST00000102899.10
    Conserved Domains (1) summary
    pfam06179
    Location:20 → 124
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26795279..26800654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62276.2 GenPept UniProtKB/Swiss-Prot:Q62276

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools