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Coq10a coenzyme Q10A [ Mus musculus (house mouse) ]

Gene ID: 210582, updated on 4-Jan-2025

Summary

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Official Symbol
Coq10aprovided by MGI
Official Full Name
coenzyme Q10Aprovided by MGI
Primary source
MGI:MGI:2684847
See related
Ensembl:ENSMUSG00000039914 AllianceGenome:MGI:2684847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1
Summary
Predicted to be active in mitochondrion. Is expressed in heart; liver; nervous system; retina nuclear layer; and testis. Orthologous to human COQ10A (coenzyme Q10A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in heart adult (RPKM 68.0), adrenal adult (RPKM 25.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Coq10a in Genome Data Viewer
Location:
10 D3; 10 76.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128198965..128204849, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128363096..128370056, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene citrate synthase Neighboring gene predicted gene, 23182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127806017-127806126 Neighboring gene ankyrin repeat domain 52 Neighboring gene microRNA 6914 Neighboring gene microRNA 6915

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway. Jing L, et al. Int J Biol Sci, 2015. PMID 25552930, Free PMC Article
  2. Lysosomal accumulation of Trk protein in brain of GM₁ -gangliosidosis mouse and its restoration by chemical chaperone. Takamura A, et al. J Neurochem, 2011 Aug. PMID 21574998
  3. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway.
    Title: Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC182861, MGC182867

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coenzyme Q-binding protein COQ10 homolog A, mitochondrial
Names
coenzyme Q10 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081040.2 → NP_001074509.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC090489
    Consensus CDS
    CCDS36089.1
    UniProtKB/TrEMBL
    E9Q3H6
    Related
    ENSMUSP00000036213.6, ENSMUST00000043211.7
    Conserved Domains (1) summary
    cd07813
    Location:89 → 237
    COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

  2. NM_001374700.2 → NP_001361629.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090489
    Consensus CDS
    CCDS88110.1
    UniProtKB/TrEMBL
    A0A1W2P7J1
    Related
    ENSMUSP00000151645.2, ENSMUST00000220227.2
    Conserved Domains (1) summary
    cd07813
    Location:89 → 227
    COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

  3. NM_001416566.1 → NP_001403495.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090489

  4. NM_001416567.1 → NP_001403496.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090489
    UniProtKB/TrEMBL
    A0A1W2P7G5
    Related
    ENSMUSP00000151609.2, ENSMUST00000220027.2

RNA

  1. NR_184315.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090489

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128198965..128204849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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