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Ints9 integrator complex subunit 9 [ Mus musculus (house mouse) ]

Gene ID: 210925, updated on 27-Nov-2024

Summary

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Official Symbol
Ints9provided by MGI
Official Full Name
integrator complex subunit 9provided by MGI
Primary source
MGI:MGI:1098533
See related
Ensembl:ENSMUSG00000021975 AllianceGenome:MGI:1098533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D14Ertd231e
Summary
Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway and snRNA 3'-end processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of integrator complex. Orthologous to human INTS9 (integrator complex subunit 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 12.8), limb E14.5 (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ints9 in Genome Data Viewer
Location:
14 D1; 14 33.81 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65187494..65277284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64950045..65039835)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65534306-65534489 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65568546-65568932 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:65644927-65645227 Neighboring gene predicted gene, 52118 Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65716318-65716519 Neighboring gene STARR-positive B cell enhancer ABC_E11573 Neighboring gene predicted gene, 52119 Neighboring gene STARR-positive B cell enhancer ABC_E388 Neighboring gene STARR-seq mESC enhancer starr_36964 Neighboring gene predicted gene, 30008 Neighboring gene predicted gene, 41177

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
  2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator complex subunit 9
Names
int9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253731.1 → NP_001240660.1  integrator complex subunit 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK077634, BQ033503, BY195822
    UniProtKB/TrEMBL
    A0A0R4J0J5
    Conserved Domains (2) summary
    smart01027
    Location:283 → 401
    Beta-Casp; Beta-Casp domain
    cl23716
    Location:60 → 241
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  2. NM_153414.5 → NP_700463.3  integrator complex subunit 9 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC141425, AC155172
    Consensus CDS
    CCDS27210.1
    UniProtKB/Swiss-Prot
    Q8BP62, Q8CAE4, Q8K114
    UniProtKB/TrEMBL
    A0A0R4J0J5
    Related
    ENSMUSP00000045552.7, ENSMUST00000043914.8
    Conserved Domains (2) summary
    smart01027
    Location:307 → 425
    Beta-Casp; Beta-Casp domain
    cd16294
    Location:1 → 265
    Int9-like_MBL-fold; integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65187494..65277284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K114.1 GenPept UniProtKB/Swiss-Prot:Q8K114

Gene LinkOut

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