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Dennd6a DENN domain containing 6A [ Mus musculus (house mouse) ]

Gene ID: 211922, updated on 4-Jan-2025

Summary

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Official Symbol
Dennd6aprovided by MGI
Official Full Name
DENN domain containing 6Aprovided by MGI
Primary source
MGI:MGI:2442980
See related
Ensembl:ENSMUSG00000040818 AllianceGenome:MGI:2442980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam116a
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell-cell adhesion mediated by cadherin. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in recycling endosome. Orthologous to human DENND6A (DENN domain containing 6A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 4.7), bladder adult (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd6a in Genome Data Viewer
Location:
14 A3; 14 16.09 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26295013..26355477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26573858..26634322)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Kruppel-like factor 17 pseudogene Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36241 Neighboring gene ARF GTPase 4 Neighboring gene phosphodiesterase 12 Neighboring gene microRNA 7672

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  2. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38041, mFLJ00229, A630054L15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-cell adhesion mediated by cadherin ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein DENND6A
Names
DENN domain-containing protein 6A
DENN/MADD domain containing 6A
family with sequence similarity 116, member A
protein FAM116A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134465.2 → NP_001127937.1  protein DENND6A isoform a

    See identical proteins and their annotated locations for NP_001127937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC121919, AK054295, AK131163
    Consensus CDS
    CCDS49430.1
    UniProtKB/Swiss-Prot
    Q3UX21, Q6KAP4, Q8BH65, Q8BSG0, Q8C4Z7, Q8K2E8, Q8R136
    Related
    ENSMUSP00000039361.8, ENSMUST00000037585.9
    Conserved Domains (2) summary
    pfam08616
    Location:267 → 370
    SPA; Stabilization of polarity axis
    cl11519
    Location:168 → 356
    DENN; DENN (AEX-3) domain

  2. NM_001285466.1 → NP_001272395.1  protein DENND6A isoform c

    See identical proteins and their annotated locations for NP_001272395.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AC121919, AK033036, AK131163
    Consensus CDS
    CCDS88601.1
    UniProtKB/Swiss-Prot
    Q8BH65
    Related
    ENSMUSP00000152966.2, ENSMUST00000224248.2
    Conserved Domains (1) summary
    cl40631
    Location:43 → 146
    SPA; Stabilization of polarity axis

  3. NM_001285467.1 → NP_001272396.1  protein DENND6A isoform c

    See identical proteins and their annotated locations for NP_001272396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AC121919, AK131163, AK135953, AK163396
    Consensus CDS
    CCDS88601.1
    UniProtKB/Swiss-Prot
    Q8BH65
    Related
    ENSMUSP00000153187.2, ENSMUST00000224111.2
    Conserved Domains (1) summary
    cl40631
    Location:43 → 146
    SPA; Stabilization of polarity axis

  4. NM_145969.4 → NP_666081.1  protein DENND6A isoform b

    See identical proteins and their annotated locations for NP_666081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC132111, AK054295, AK131163, AK161908
    Consensus CDS
    CCDS84101.1
    UniProtKB/Swiss-Prot
    Q8BH65
    Related
    ENSMUSP00000144906.2, ENSMUST00000203874.3
    Conserved Domains (2) summary
    pfam08616
    Location:267 → 370
    SPA; Stabilization of polarity axis
    cl11519
    Location:168 → 356
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    26295013..26355477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158533.1 → XP_036014426.1  protein DENND6A isoform X1

    Conserved Domains (1) summary
    cl40631
    Location:43 → 146
    SPA; Stabilization of polarity axis

  2. XM_006518778.1 → XP_006518841.1  protein DENND6A isoform X1

    See identical proteins and their annotated locations for XP_006518841.1

    UniProtKB/Swiss-Prot
    Q8BH65
    Conserved Domains (1) summary
    cl40631
    Location:43 → 146
    SPA; Stabilization of polarity axis
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH65.1 GenPept UniProtKB/Swiss-Prot:Q8BH65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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