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Plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 [ Mus musculus (house mouse) ]

Gene ID: 211945, updated on 27-Nov-2024

Summary

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Official Symbol
Plekhh1provided by MGI
Official Full Name
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1provided by MGI
Primary source
MGI:MGI:2144989
See related
Ensembl:ENSMUSG00000060716 AllianceGenome:MGI:2144989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1200; D630024D12Rik
Summary
Predicted to be located in cytoskeleton. Is expressed in genitourinary system. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 18.0), colon adult (RPKM 15.8) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Plekhh1 in Genome Data Viewer
Location:
12 C3; 12 35.51 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79075937..79128429)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (79029163..79081655)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46359 Neighboring gene STARR-seq mESC enhancer starr_32581 Neighboring gene predicted gene, 46360 Neighboring gene STARR-seq mESC enhancer starr_32582 Neighboring gene transmembrane protein 229B Neighboring gene STARR-seq mESC enhancer starr_32583 Neighboring gene STARR-seq mESC enhancer starr_32585 Neighboring gene STARR-seq mESC enhancer starr_32589 Neighboring gene predicted gene, 53729 Neighboring gene RIKEN cDNA 9230116L04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10760 Neighboring gene STARR-seq mESC enhancer starr_32591 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H Neighboring gene ribosomal protein large PO subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Gómez-Del Arco P, et al. Nat Commun, 2024 Oct 4. PMID 39366945, Free PMC Article
  2. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family H member 1
Names
PH domain-containing family H member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181073.3 → NP_851418.2  pleckstrin homology domain-containing family H member 1

    See identical proteins and their annotated locations for NP_851418.2

    Status: VALIDATED

    Source sequence(s)
    AA072901, AK143387, BQ031023, CF538481, CJ106785
    Consensus CDS
    CCDS49097.1
    UniProtKB/Swiss-Prot
    Q3UPN4, Q80TI1, Q8BWF3, Q8K334, Q99JL2
    Related
    ENSMUSP00000049460.6, ENSMUST00000039928.7
    Conserved Domains (7) summary
    smart00139
    Location:826 → 980
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:682 → 785
    PH; Pleckstrin homology domain
    smart00295
    Location:993 → 1224
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1220 → 1321
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:575 → 670
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl28922
    Location:990 → 1096
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    79075937..79128429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515646.3 → XP_006515709.1  pleckstrin homology domain-containing family H member 1 isoform X2

    Conserved Domains (8) summary
    smart00139
    Location:826 → 980
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:682 → 785
    PH; Pleckstrin homology domain
    smart00295
    Location:993 → 1224
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK05563
    Location:100 → 269
    PRK05563; DNA polymerase III subunits gamma and tau; Validated
    cd13282
    Location:575 → 670
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:1220 → 1320
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:990 → 1096
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_036157303.1 → XP_036013196.1  pleckstrin homology domain-containing family H member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UPN4, Q80TI1, Q8BWF3, Q8K334, Q99JL2
    Related
    ENSMUSP00000151747.2, ENSMUST00000219956.2
    Conserved Domains (7) summary
    smart00139
    Location:826 → 980
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:682 → 785
    PH; Pleckstrin homology domain
    smart00295
    Location:993 → 1224
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13206
    Location:1220 → 1321
    FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
    cd13282
    Location:575 → 670
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl28922
    Location:990 → 1096
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TI1.2 GenPept UniProtKB/Swiss-Prot:Q80TI1

Gene LinkOut

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