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Tacc3 transforming, acidic coiled-coil containing protein 3 [ Mus musculus (house mouse) ]

Gene ID: 21335, updated on 4-Jan-2025

Summary

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Official Symbol
Tacc3provided by MGI
Official Full Name
transforming, acidic coiled-coil containing protein 3provided by MGI
Primary source
MGI:MGI:1341163
See related
Ensembl:ENSMUSG00000037313 AllianceGenome:MGI:1341163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aint; Eric1
Summary
Enables protein domain specific binding activity. Acts upstream of or within several processes, including astral microtubule organization; cytoplasmic sequestering of transcription factor; and nervous system development. Located in centrosome and cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human TACC3 (transforming acidic coiled-coil containing protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E11.5 (RPKM 34.6), liver E14 (RPKM 25.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Tacc3 in Genome Data Viewer
Location:
5 B2; 5 17.83 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33814808..33836331)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33658128..33672203)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6317 Neighboring gene predicted gene 9903 Neighboring gene STARR-positive B cell enhancer ABC_E6318 Neighboring gene stem-loop binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34000710-34000897 Neighboring gene predicted gene 10459 Neighboring gene transmembrane protein 129 Neighboring gene STARR-seq mESC enhancer starr_12827 Neighboring gene Fgfr3 5' regulatory region Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_12830 Neighboring gene ribosomal protein S29 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aint/Tacc3 is highly expressed in proliferating mouse tissues during development, spermatogenesis, and oogenesis. Aitola M, et al. J Histochem Cytochem, 2003 Apr. PMID 12642624
  2. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. Garriga-Canut M, et al. J Biol Chem, 2004 May 28. PMID 15037632
  3. Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Bargo S, et al. Biochem Biophys Res Commun, 2010 Oct 1. PMID 20804727, Free PMC Article
  4. Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding. Hood FE, et al. J Cell Biol, 2013 Aug 5. PMID 23918938, Free PMC Article
  5. Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice. Simerly C, et al. Sci Rep, 2024 Feb 27. PMID 38413710, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
    Title: Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
  2. Aurora kinase A is essential for meiosis in mouse oocytes.
    Title: Aurora kinase A is essential for meiosis in mouse oocytes.
  3. Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation.
    Title: Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation.
  4. Tacc3 is required for the proper mitosis of Apc-deficient ISCs, and its disruption significantly attenuated the expansion of the crypt domain. In vivo analysis of corresponding mutant mice demonstrated that Tacc3 disruption led to a significant decrease in tumor number and prolonged survival.
    Title: Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells.
  5. Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.
    Title: The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
  6. The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.
    Title: Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.
  7. DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
    Title: DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
  8. results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
    Title: Disruption of Tacc3 function leads to in vivo tumor regression.
  9. Tacc3 is a negative regulator of the Notch signaling pathway.
    Title: Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
  10. in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.
    Title: TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within astral microtubule organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytoplasmic sequestering of transcription factor IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within interkinetic nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metaphase/anaphase transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization involved in mitosis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming acidic coiled-coil-containing protein 3
Names
ARNT-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040435.4 → NP_001035525.1  transforming acidic coiled-coil-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001035525.1

    Status: VALIDATED

    Source sequence(s)
    AC162898
    Consensus CDS
    CCDS39065.1
    UniProtKB/TrEMBL
    Q6NV52, Q9JIQ5
    Related
    ENSMUSP00000110069.4, ENSMUST00000114426.10
    Conserved Domains (2) summary
    pfam05010
    Location:428 → 624
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl03075
    Location:426 → 580
    GrpE; nucleotide exchange factor GrpE

  2. NM_001310541.2 → NP_001297470.1  transforming acidic coiled-coil-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001297470.1

    Status: VALIDATED

    Source sequence(s)
    AC162898
    Consensus CDS
    CCDS80258.1
    UniProtKB/TrEMBL
    Q99LH8, Q9JIQ5
    Related
    ENSMUSP00000074394.7, ENSMUST00000074849.13
    Conserved Domains (2) summary
    PRK10811
    Location:144 → 294
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:435 → 631
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  3. NM_001405350.1 → NP_001392279.1  transforming acidic coiled-coil-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q9JIQ5

  4. NM_001405351.1 → NP_001392280.1  transforming acidic coiled-coil-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q9JIQ5

  5. NM_001405352.1 → NP_001392281.1  transforming acidic coiled-coil-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q9JIQ5

  6. NM_001405353.1 → NP_001392282.1  transforming acidic coiled-coil-containing protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q9JIQ5

  7. NM_001405354.1 → NP_001392283.1  transforming acidic coiled-coil-containing protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q9JIQ5

  8. NM_001405355.1 → NP_001392284.1  transforming acidic coiled-coil-containing protein 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162898

  9. NM_001405356.1 → NP_001392285.1  transforming acidic coiled-coil-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q6NV52, Q9JIQ5
    Related
    ENSMUSP00000078491.5, ENSMUST00000079534.11

  10. NM_001405357.1 → NP_001392286.1  transforming acidic coiled-coil-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q6NV52, Q9JIQ5

  11. NM_001405358.1 → NP_001392287.1  transforming acidic coiled-coil-containing protein 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q9JIQ5

  12. NM_001405360.1 → NP_001392289.1  transforming acidic coiled-coil-containing protein 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    Q9JIQ5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33814808..33836331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254350.2 → XP_030110210.1  transforming acidic coiled-coil-containing protein 3 isoform X6

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (2) summary
    PRK10811
    Location:144 → 294
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:428 → 569
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  2. XM_030254352.2 → XP_030110212.1  transforming acidic coiled-coil-containing protein 3 isoform X9

    Conserved Domains (2) summary
    PRK10811
    Location:71 → 221
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:355 → 496
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  3. XM_030254349.2 → XP_030110209.1  transforming acidic coiled-coil-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23 → 274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160 → 310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:444 → 626
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  4. XM_006503835.5 → XP_006503898.1  transforming acidic coiled-coil-containing protein 3 isoform X7

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (2) summary
    PRK10811
    Location:71 → 221
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:362 → 558
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  5. XM_011240716.4 → XP_011239018.1  transforming acidic coiled-coil-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23 → 274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160 → 310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:451 → 592
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  6. XM_011240715.1 → XP_011239017.1  transforming acidic coiled-coil-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23 → 274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160 → 310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:444 → 640
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  7. XM_036164983.1 → XP_036020876.1  transforming acidic coiled-coil-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    Q9JIQ5
    Conserved Domains (3) summary
    PRK10263
    Location:23 → 274
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:160 → 310
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:444 → 583
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  8. XM_006503832.4 → XP_006503895.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006503895.1

    UniProtKB/TrEMBL
    Q99LH8, Q9JIQ5
    Conserved Domains (2) summary
    PRK10811
    Location:144 → 294
    rne; ribonuclease E; Reviewed
    pfam05010
    Location:435 → 631
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

RNA

  1. XR_868281.4 RNA Sequence

  2. XR_003955613.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011524.3: Suppressed sequence

    Description
    NM_011524.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJ11.1 GenPept UniProtKB/Swiss-Prot:Q9JJ11

Gene LinkOut

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