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Lemd1 LEM domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 213409, updated on 4-Jan-2025

Summary

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Official Symbol
Lemd1provided by MGI
Official Full Name
LEM domain containing 1provided by MGI
Primary source
MGI:MGI:1922403
See related
Ensembl:ENSMUSG00000079330 AllianceGenome:MGI:1922403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LEMP-1; 4930540I23Rik; 6430514M23Rik
Summary
Orthologous to human LEMD1 (LEM domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in testis adult (RPKM 12.8), CNS E14 (RPKM 1.7) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Lemd1 in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132118361..132185120)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132190629..132257382)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30153 Neighboring gene STARR-positive B cell enhancer mm9_chr1:134052383-134052684 Neighboring gene predicted gene, 30242 Neighboring gene predicted gene, 29695 Neighboring gene STARR-seq mESC enhancer starr_02235 Neighboring gene microRNA 135b Neighboring gene STARR-seq mESC enhancer starr_02242 Neighboring gene predicted gene 29630 Neighboring gene STARR-seq mESC enhancer starr_02247 Neighboring gene predicted gene, 38446 Neighboring gene predicted pseudogene 7241

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
LEM domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033250.4 → NP_001028422.2  LEM domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001028422.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1, that results in a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK144269, BC115462, CO040031
    Consensus CDS
    CCDS35705.1
    UniProtKB/Swiss-Prot
    Q14C37
    Related
    ENSMUSP00000107976.3, ENSMUST00000112357.9
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  2. NM_001311102.1 → NP_001298031.1  LEM domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001298031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124108, AC160545, AK016010, AK144269, CO040031
    Consensus CDS
    CCDS78679.1
    UniProtKB/TrEMBL
    A0A087WQH1
    Related
    ENSMUSP00000140193.2, ENSMUST00000191418.2
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  3. NM_001311103.1 → NP_001298032.1  LEM domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, which results in translation initiation from a downstream AUG. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC124108, AK016010, BY715589, CO040031

  4. NM_001311104.1 → NP_001298033.1  LEM domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001298033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that results in a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK144269, CO040031
    Consensus CDS
    CCDS83590.1
    UniProtKB/TrEMBL
    A0A087WR92
    Related
    ENSMUSP00000140524.2, ENSMUST00000188169.7
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

RNA

  1. NR_132336.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124108, AK016010, CO040031
    Related
    ENSMUST00000185436.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132118361..132185120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163412.1 → XP_036019305.1  LEM domain-containing protein 1 isoform X3

  2. XM_006529349.3 → XP_006529412.1  LEM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006529412.1

    UniProtKB/TrEMBL
    A0A087WQH1
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  3. XM_006529347.3 → XP_006529410.1  LEM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006529410.1

    UniProtKB/TrEMBL
    A0A087WQH1
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  4. XM_006529348.4 → XP_006529411.1  LEM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006529411.1

    UniProtKB/TrEMBL
    A0A087WQH1
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  5. XM_011247970.2 → XP_011246272.1  LEM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011246272.1

    UniProtKB/TrEMBL
    A0A087WQH1
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  6. XM_006529352.4 → XP_006529415.1  LEM domain-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006529415.1

    UniProtKB/TrEMBL
    A0A087WR92
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  7. XM_036163414.1 → XP_036019307.1  LEM domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    pfam03020
    Location:3 → 42
    LEM; LEM domain

  8. XM_006529351.4 → XP_006529414.1  LEM domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006529414.1

    UniProtKB/Swiss-Prot
    Q14C37
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

  9. XM_006529350.5 → XP_006529413.1  LEM domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006529413.1

    UniProtKB/TrEMBL
    A0A087WQH1
    Conserved Domains (1) summary
    cd12940
    Location:3 → 44
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14C37.1 GenPept UniProtKB/Swiss-Prot:Q14C37

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