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Duox2 dual oxidase 2 [ Mus musculus (house mouse) ]

Gene ID: 214593, updated on 9-Dec-2024

Summary

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Official Symbol
Duox2provided by MGI
Official Full Name
dual oxidase 2provided by MGI
Primary source
MGI:MGI:3036280
See related
Ensembl:ENSMUSG00000068452 AllianceGenome:MGI:3036280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LNOX2; THOX2; NOXEF2; P138-TOX; A430065P05Rik
Summary
Predicted to enable NAD(P)H oxidase H2O2-forming activity; calcium ion binding activity; and superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within several processes, including bone mineralization; endocrine system development; and thyroid hormone metabolic process. Predicted to be located in several cellular components, including cell leading edge; cell surface; and endoplasmic reticulum. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in placenta and thyroid gland. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in large intestine adult (RPKM 68.1), small intestine adult (RPKM 25.6) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Duox2 in Genome Data Viewer
Location:
2 E5; 2 60.61 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122109727..122129221, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122279246..122298740, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S12, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_05551 Neighboring gene sorbitol dehydrogenase Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epithelial Dual Oxidase 2 Shapes the Mucosal Microbiome and Contributes to Inflammatory Susceptibility. Castrillón-Betancur JC, et al. Antioxidants (Basel), 2023 Oct 21. PMID 37891968, Free PMC Article
  2. Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice. Kim MJ, et al. Antioxid Redox Signal, 2014 Nov 1. PMID 24766345, Free PMC Article
  3. Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2. Donkó Á, et al. Free Radic Biol Med, 2014 Aug. PMID 24853759, Free PMC Article
  4. The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium. Sommer F, et al. Mucosal Immunol, 2015 Mar. PMID 25160818
  5. Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism. Hong SN, et al. Antiviral Res, 2016 Oct. PMID 27546489

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestinal Epithelial Inactivity of Dual Oxidase 2 Results in Microbiome-Mediated Metabolic Syndrome.
    Title: Intestinal Epithelial Inactivity of Dual Oxidase 2 Results in Microbiome-Mediated Metabolic Syndrome.
  2. Telocytes reduce oxidative stress by downregulating DUOX2 expression in inflamed lungs of mice.
    Title: Telocytes reduce oxidative stress by downregulating DUOX2 expression in inflamed lungs of mice.
  3. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.
    Title: DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.
  4. Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
    Title: Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
  5. All these results reveal a critical role of Duox2 in the infection-induced H2O2 production and the H2O2-mediated immune response to infection in the respiratory tract.
    Title: Chemiluminescence imaging of Duox2-derived hydrogen peroxide for longitudinal visualization of biological response to viral infection in nasal mucosa.
  6. The findings illustrate for the first time that the extreme C-terminus of Duox2 is required for the functional activity of the enzyme .
    Title: CRISPR/Cas9-mediated modification of the extreme C-terminus impairs PDGF-stimulated activity of Duox2.
  7. Duox2 is necessary for the regulation of IFN secretion in in vivo lung, and pulmonary administration of Duox2 DNA using cationic polymer triggers the induction of type I and III IFNs resulting in more complete suppression of influenza A virus infection.
    Title: Intranasal delivery of Duox2 DNA using cationic polymer can prevent acute influenza A viral infection in vivo lung.
  8. Both Nox1 and Duox2 induce exfoliation of crypt epithelium, but only Nox1 induces apoptosis. NOX1 and DUOX2 may be potential therapeutic targets for treating ileocolitis in human patients suffering inflammatory bowel disease (IBD).
    Title: Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
  9. dual oxidase-2 and IL-6 play important roles in GPR43-mediated skin inflammation.
    Title: GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model.
  10. We propose that Duox2 is responsible for IFN-independent signaling for induction of pattern recognition receptors transcription and can control acute Influenza virus A infection at the beginning of infection.
    Title: Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)H oxidase H2O2-forming activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adenohypophysis morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in superoxide anion generation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within thyroid gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thyroid hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual oxidase 2
NP_001349684.1
XP_006499173.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362755.1 → NP_001349684.1  dual oxidase 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844566
    Consensus CDS
    CCDS89548.1
    UniProtKB/TrEMBL
    A0A494BAW1, B7ZWM4
    Related
    ENSMUSP00000158204.2, ENSMUST00000237546.2
    Conserved Domains (4) summary
    cd06186
    Location:1271 → 1545
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38 → 594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824 → 885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1085 → 1229
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122109727..122129221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499110.3 → XP_006499173.1  dual oxidase 2 isoform X1

    UniProtKB/TrEMBL
    A0A494BAW1, B7ZWM4
    Conserved Domains (4) summary
    cd06186
    Location:1271 → 1545
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38 → 594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824 → 885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1085 → 1229
    Ferric_reduct; Ferric reductase like transmembrane component

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177610.2: Suppressed sequence

    Description
    NM_177610.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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