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Hdhd5 haloacid dehalogenase like hydrolase domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 214932, updated on 27-Nov-2024

Summary

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Official Symbol
Hdhd5provided by MGI
Official Full Name
haloacid dehalogenase like hydrolase domain containing 5provided by MGI
Primary source
MGI:MGI:2136976
See related
Ensembl:ENSMUSG00000058979 AllianceGenome:MGI:2136976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cecr5; A930002G03Rik
Summary
Predicted to be involved in glycerophospholipid biosynthetic process. Located in mitochondrion. Orthologous to human HDHD5 (haloacid dehalogenase like hydrolase domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 11.2), kidney adult (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hdhd5 in Genome Data Viewer
Location:
6 F1; 6 56.95 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120486453..120508319, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120509492..120531363, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120416743-120416991 Neighboring gene STARR-positive B cell enhancer ABC_E685 Neighboring gene STARR-positive B cell enhancer ABC_E10406 Neighboring gene interleukin 17 receptor A Neighboring gene transmembrane protein 121B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120479310-120479463 Neighboring gene RIKEN cDNA 1700072O05 gene Neighboring gene nonconserved acetylation island sequence M73 enhancer Neighboring gene STARR-positive B cell enhancer ABC_E6478 Neighboring gene STARR-positive B cell enhancer ABC_E8125 Neighboring gene CECR2, histone acetyl-lysine reader Neighboring gene predicted gene, 53339

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. Footz TK, et al. Genome Res, 2001 Jun. PMID 11381032, Free PMC Article
  2. Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes. Szakats S, et al. Biol Sex Differ, 2023 Sep 7. PMID 37679839, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC25951

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
haloacid dehalogenase-like hydrolase domain-containing 5
Names
cat eye syndrome chromosome region, candidate 5 homolog
cat eye syndrome critical region protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144815.2 → NP_659064.1  haloacid dehalogenase-like hydrolase domain-containing 5 precursor

    See identical proteins and their annotated locations for NP_659064.1

    Status: VALIDATED

    Source sequence(s)
    BC014705
    Consensus CDS
    CCDS20483.1
    UniProtKB/Swiss-Prot
    Q91WM2
    Related
    ENSMUSP00000074775.7, ENSMUST00000075303.7
    Conserved Domains (2) summary
    TIGR01456
    Location:47 → 358
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5
    pfam13344
    Location:49 → 152
    Hydrolase_6; Haloacid dehalogenase-like hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    120486453..120508319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255305.1 → XP_030111165.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

    Conserved Domains (1) summary
    TIGR01456
    Location:1 → 236
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  2. XM_036166013.1 → XP_036021906.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

    Conserved Domains (1) summary
    TIGR01456
    Location:1 → 236
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  3. XM_036166014.1 → XP_036021907.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X3

    Conserved Domains (1) summary
    TIGR01456
    Location:1 → 190
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  4. XM_011241282.3 → XP_011239584.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X2

    See identical proteins and their annotated locations for XP_011239584.1

    Conserved Domains (1) summary
    TIGR01456
    Location:24 → 192
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  5. XM_030255308.1 → XP_030111168.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

    Conserved Domains (1) summary
    TIGR01456
    Location:1 → 151
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  6. XM_030255309.1 → XP_030111169.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

    Conserved Domains (1) summary
    TIGR01456
    Location:1 → 151
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  7. XM_030255307.2 → XP_030111167.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

    Conserved Domains (1) summary
    TIGR01456
    Location:1 → 151
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  8. XM_036166015.1 → XP_036021908.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

    Conserved Domains (1) summary
    TIGR01456
    Location:1 → 151
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

RNA

  1. XR_868852.4 RNA Sequence

  2. XR_003956182.2 RNA Sequence

  3. XR_003956183.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WM2.1 GenPept UniProtKB/Swiss-Prot:Q91WM2

Gene LinkOut

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