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Tcrb T cell receptor beta chain [ Mus musculus (house mouse) ]

Gene ID: 21577, updated on 26-Nov-2024

Summary

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Official Symbol
Tcrbprovided by MGI
Official Full Name
T cell receptor beta chainprovided by MGI
Primary source
MGI:MGI:98578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tib; TCRbeta
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes several trypsinogen genes. [provided by RefSeq, Jul 2008]
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Genomic context

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See Tcrb in Genome Data Viewer
Location:
6 B1; 6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40868230..41535305)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40891296..41558371)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene maltase-glucoamylase 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_15690 Neighboring gene RIKEN cDNA 1810009J06 gene Neighboring gene monooxygenase, DBH-like 2 Neighboring gene serine protease 58 Neighboring gene T cell receptor beta, variable 1 Neighboring gene serine protease 59 Neighboring gene trypsinogen pseudogene Neighboring gene STARR-seq mESC enhancer starr_15692 Neighboring gene STARR-positive B cell enhancer mm9_chr6:41005535-41005835 Neighboring gene predicted gene 2663 Neighboring gene serine protease 3B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:41063415-41063598 Neighboring gene T cell receptor beta, variable 2 Neighboring gene T cell receptor beta, variable 3 Neighboring gene T cell receptor beta, variable 10 Neighboring gene T cell receptor beta, variable 5 Neighboring gene T cell receptor beta variable 6 Neighboring gene STARR-seq mESC enhancer starr_15693 Neighboring gene T cell receptor beta, variable 12-1 Neighboring gene T cell receptor beta variable 7 Neighboring gene T cell receptor beta variable 10 Neighboring gene T cell receptor beta, variable 13-1 Neighboring gene T cell receptor beta, variable 12-2 Neighboring gene T cell receptor beta variable 8 Neighboring gene STARR-seq mESC enhancer starr_15694 Neighboring gene T cell receptor beta, variable 13-2 Neighboring gene T cell receptor beta variable 9 Neighboring gene T cell receptor beta, variable 12-3 Neighboring gene T cell receptor beta variable 11 Neighboring gene T cell receptor beta, variable 13-3 Neighboring gene T cell receptor beta, variable 14 Neighboring gene T cell receptor beta, variable 15 Neighboring gene T cell receptor beta, variable 16 Neighboring gene T cell receptor beta, variable 17 Neighboring gene STARR-seq mESC enhancer starr_15695 Neighboring gene T cell receptor beta variable 18 Neighboring gene T cell receptor beta, variable 19 Neighboring gene T cell receptor beta, variable 20 Neighboring gene T cell receptor beta, variable 21 Neighboring gene T cell receptor beta variable 22 Neighboring gene T cell receptor beta, variable V23 Neighboring gene T cell receptor beta, variable 24 Neighboring gene T cell receptor beta variable 25 Neighboring gene T cell receptor beta, variable 26 Neighboring gene STARR-seq mESC enhancer starr_15697 Neighboring gene protein tyrosine phosphatase domain containing 1 pseudogene Neighboring gene T cell receptor beta variable 27 Neighboring gene T cell receptor beta variable 28 Neighboring gene T cell receptor beta variable 29 Neighboring gene T cell receptor beta, variable 30 Neighboring gene cell division cycle 42 homolog pseudogene Neighboring gene trypsin 4 Neighboring gene trypsin 5 Neighboring gene STARR-seq mESC enhancer starr_15698 Neighboring gene trypsin 10 Neighboring gene serine protease 3 Neighboring gene serine protease 1 (trypsin 1) like Neighboring gene STARR-seq mESC enhancer starr_15699 Neighboring gene Try10-like trypsinogen pseudogene Neighboring gene serine protease 3 like Neighboring gene STARR-seq mESC enhancer starr_15700 Neighboring gene STARR-positive B cell enhancer mm9_chr6:41480095-41480396 Neighboring gene serine protease 1 (trypsin 1) Neighboring gene STARR-seq mESC enhancer starr_15701 Neighboring gene proline-rich polypeptide 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:41504290-41504605 Neighboring gene STARR-seq mESC enhancer starr_15702 Neighboring gene STARR-seq mESC enhancer starr_15703 Neighboring gene T cell receptor beta joining 1-3 Neighboring gene T cell receptor beta joining 1-2 Neighboring gene T cell receptor beta joining 1-1 Neighboring gene T cell receptor beta joining 1-5 Neighboring gene T cell receptor beta joining 1-6 Neighboring gene T cell receptor beta joining 1-7 Neighboring gene T cell receptor beta joining 1-4 Neighboring gene STARR-seq mESC enhancer starr_15704 Neighboring gene T cell receptor beta joining 2-5 Neighboring gene T cell receptor beta joining 2-6 Neighboring gene T cell receptor beta joining 2-4 Neighboring gene T cell receptor beta joining 2-3 Neighboring gene T cell receptor beta joining 2-2 Neighboring gene T cell receptor beta joining 2-1 Neighboring gene T cell receptor beta joining 2-7 Neighboring gene serine protease 2 Neighboring gene T cell receptor beta, D region 1 Neighboring gene T cell receptor beta, constant region 1 Neighboring gene T cell receptor beta, D region 2 Neighboring gene T cell receptor beta, constant 2 Neighboring gene T cell receptor beta, variable 31 Neighboring gene predicted gene, 27549 Neighboring gene Eph receptor B6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes. Amrani A, et al. J Clin Invest, 2000 Feb. PMID 10683375, Free PMC Article
  2. Influence of T-cell receptor genes on chronic experimental autoimmune encephalomyelitis. Jansson L, et al. Immunogenetics, 1993. PMID 7679665
  3. gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice. Naiki Y, et al. Cell Immunol, 2000 May 25. PMID 10873307
  4. The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression. Tyagi AM, et al. Immunity, 2018 Dec 18. PMID 30446387, Free PMC Article
  5. Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. Sasada T, et al. J Exp Med, 2002 Jun 3. PMID 12045240, Free PMC Article

See all (858) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Type B thymomas in patients with myasthenia gravis display a distinctive pattern of alphabeta TCR and IL-7 receptor alpha expression on CD4[+]CD8[+] thymocytes.
    Title: Type B thymomas in patients with myasthenia gravis display a distinctive pattern of αβ TCR and IL-7 receptor α expression on CD4(+)CD8(+) thymocytes.
  2. The Cyclin D3 Protein Enforces Monogenic TCRbeta Expression by Mediating TCRbeta Protein-Signaled Feedback Inhibition of Vbeta Recombination.
    Title: The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination.
  3. Characterization of transcripts emanating from enhancer Ebeta of the murine TCRbeta locus.
    Title: Characterization of transcripts emanating from enhancer Eβ of the murine TCRβ locus.
  4. study indicates two successive inversional Vbeta-to-DJbeta rearrangements on the same allele can contribute to the TCRbeta repertoire
    Title: Two Successive Inversional Vβ Rearrangements on a Single Tcrb Allele Can Contribute to the TCRβ Repertoire.
  5. About 10% of peripheral T cells express 2 functional TCR alphabeta heterodimers. Lack of dual TCR expression resulted in reduced lymphopenia-induced proliferation. Dual TCR expression enhances T cell homeostasis via increased reactivity against self-peptide:MHC (pMHC) ligands.
    Title: Endogenous co-expression of two T cell receptors promotes lymphopenia-induced proliferation via increased affinity for self-antigen.
  6. TCRbeta-expressing macrophages induced by a pathogenic murine malaria correlate with parasite burden and enhanced phagocytic activity
    Title: TCRβ-expressing macrophages induced by a pathogenic murine malaria correlate with parasite burden and enhanced phagocytic activity.
  7. the roles of Runx complexes in the regulation of the TCRbeta enhancer function, were examined.
    Title: Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.
  8. The authors show that positive selection-induced MHC bias of T cell receptors is affected both by the germline encoded elements of the T cell receptor alpha and beta chain and, surprisingly, dramatically affected by the non germ line encoded portions of CDR3 complementary determining loop of the T cell receptor alpha chain.
    Title: The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.
  9. single TCRbeta are sufficient to confer on TCRalphabeta chains reactivity toward disease-associated autoantigens in the context of diverse TCRalpha.
    Title: Autoimmune susceptibility imposed by public TCRβ chains.
  10. this study shows that decreased expression levels of Ifi gene 200 cluster is associated to the increased resistance to spontaneous arthritis disease and with down regulation of expressions of Tcrb genes in the mouse congenic strain
    Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Submit: New GeneRIF Correction See all GeneRIFs (93)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to parathyroid hormone stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of ossification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha-beta T cell receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Names
T cell receptor beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_006980.1 

    Range
    502..667577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    40868230..41535305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials