Polrmt polymerase (RNA) mitochondrial (DNA directed) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Polrmtprovided by MGI
Official Full Name: polymerase (RNA) mitochondrial (DNA directed)provided by MGI
Primary source: MGI:MGI:1915843
See related: Ensembl:ENSMUSG00000020329 AllianceGenome:MGI:1915843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mtRPOL; 4932416K13; 1110018N15Rik
Summary: Enables sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at mitochondrial promoter. Located in mitochondrion. Part of protein-containing complex. Is expressed in early conceptus; limb mesenchyme; and secondary oocyte. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 55. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 26.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79571951..79582436, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79736125..79746604, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
Title: SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
we present in vivo evidence that POLRMT has a key regulatory role in the replication of mammalian mtDNA and is part of a transcriptional mechanism that provides a switch between primer formation for mtDNA replication and mitochondrial gene expression.
Title: POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.
POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition
Title: The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Polrmt (e-PCR), detects polymorphism
- UniSTS:496727

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA primase activity	ISO Inferred from Sequence Orthology more info
enables DNA primase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-directed 5'-3' RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed 5'-3' RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase I activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase IV activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase V activity	IEA Inferred from Electronic Annotation more info
enables mitochondrial promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial single subunit type RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables plastid single subunit type RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication, synthesis of primer	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in plastid transcription	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase IV	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase V	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at mitochondrial promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at mitochondrial promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial DNA-directed RNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-directed RNA polymerase, mitochondrial

Names: mitochondrial DNA-directed RNA polymerase

NP_001394721.1

EC 2.7.7.6

NP_001394722.1

EC 2.7.7.6

NP_001394723.1

EC 2.7.7.6

NP_001394724.1

EC 2.7.7.6

NP_001394725.1

EC 2.7.7.6

NP_001394726.1

EC 2.7.7.6

NP_001394727.1

EC 2.7.7.6

NP_001394728.1

EC 2.7.7.6

NP_766139.2

EC 2.7.7.6

XP_030100878.1

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001407792.1 → NP_001394721.1 DNA-directed RNA polymerase, mitochondrial isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC151828
NM_001407793.1 → NP_001394722.1 DNA-directed RNA polymerase, mitochondrial isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC151828
NM_001407794.1 → NP_001394723.1 DNA-directed RNA polymerase, mitochondrial isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC151828
NM_001407795.1 → NP_001394724.1 DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC151828

UniProtKB/TrEMBL

E9PWD9

Related

ENSMUSP00000124936.2, ENSMUST00000159016.8
NM_001407796.1 → NP_001394725.1 DNA-directed RNA polymerase, mitochondrial isoform 6

Status: VALIDATED

Source sequence(s)

AC151828
NM_001407797.1 → NP_001394726.1 DNA-directed RNA polymerase, mitochondrial isoform 6

Status: VALIDATED

Source sequence(s)

AC151828
NM_001407798.1 → NP_001394727.1 DNA-directed RNA polymerase, mitochondrial isoform 6

Status: VALIDATED

Source sequence(s)

AC151828
NM_001407799.1 → NP_001394728.1 DNA-directed RNA polymerase, mitochondrial isoform 7

Status: VALIDATED

Source sequence(s)

AC151828
NM_172551.4 → NP_766139.2 DNA-directed RNA polymerase, mitochondrial isoform 2 precursor

See identical proteins and their annotated locations for NP_766139.2

Status: VALIDATED

Source sequence(s)

AC151828

Consensus CDS

CCDS23987.1

UniProtKB/Swiss-Prot

Q8BJE0, Q8BKF1

UniProtKB/TrEMBL

Q3U3J3, Q3V3C0

Related

ENSMUSP00000020580.7, ENSMUST00000020580.13

Conserved Domains (4) summary

PHA00452
Location:437 → 1207

PHA00452; T3/T7-like RNA polymerase

sd00004
Location:233 → 262

PPR; PPR repeat [structural motif]

pfam00940
Location:802 → 1206

RNA_pol; DNA-dependent RNA polymerase

pfam14700
Location:374 → 674

RPOL_N; DNA-directed RNA polymerase N-terminal

RNA

NR_176423.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC151828

Related

ENSMUST00000162694.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79571951..79582436 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245018.2 → XP_030100878.1 DNA-directed RNA polymerase, mitochondrial isoform X1

UniProtKB/TrEMBL

Q3V3C0

Conserved Domains (3) summary

sd00004
Location:233 → 262

PPR; PPR repeat [structural motif]

pfam00940
Location:802 → 1236

RNA_pol; DNA-dependent RNA polymerase

pfam14700
Location:375 → 675

RPOL_N; DNA-directed RNA polymerase N-terminal