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Rdh19 retinol dehydrogenase 19 [ Mus musculus (house mouse) ]

Gene ID: 216453, updated on 27-Nov-2024

Summary

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Official Symbol
Rdh19provided by MGI
Official Full Name
retinol dehydrogenase 19provided by MGI
Primary source
MGI:MGI:2678390
See related
Ensembl:ENSMUSG00000054052 AllianceGenome:MGI:2678390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rdhs; RDH-S; RDH-S2
Summary
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; and androsterone dehydrogenase activity. Predicted to be involved in positive regulation of retinoic acid biosynthetic process; retinoid metabolic process; and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 16.1), kidney adult (RPKM 5.1) and 4 other tissues See more
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Genomic context

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See Rdh19 in Genome Data Viewer
Location:
10 D3; 10 76.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127685797..127697045)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127849928..127861176)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16 Neighboring gene STARR-seq mESC enhancer starr_28238 Neighboring gene STARR-seq mESC enhancer starr_28239 Neighboring gene retinol dehydrogenase 18, pseudogene Neighboring gene STARR-seq mESC enhancer starr_28240 Neighboring gene RDH16 family member 2 Neighboring gene predicted gene, 31091 Neighboring gene retinol dehydrogenase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a mouse short-chain dehydrogenase/reductase gene, retinol dehydrogenase-similar. Function of non-catalytic amino acid residues in enzyme activity. Song MS, et al. J Biol Chem, 2003 Oct 10. PMID 12855677
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables all-trans-retinol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinol dehydrogenase similar protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147222.2 → NP_671755.2  retinol dehydrogenase similar protein 2 precursor

    See identical proteins and their annotated locations for NP_671755.2

    Status: VALIDATED

    Source sequence(s)
    AC131690
    Consensus CDS
    CCDS24253.1
    UniProtKB/TrEMBL
    G5E8H9, Q8K3M9
    Related
    ENSMUSP00000076735.3, ENSMUST00000077530.3
    Conserved Domains (2) summary
    cd09805
    Location:30 → 306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:30 → 219
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127685797..127697045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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