Rufy1 RUN and FYVE domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rufy1provided by MGI
Official Full Name: RUN and FYVE domain containing 1provided by MGI
Primary source: MGI:MGI:2429762
See related: Ensembl:ENSMUSG00000020375 AllianceGenome:MGI:2429762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rabip4; ZFYVE12; 3000002E04Rik
Summary: Predicted to enable identical protein binding activity; protein domain specific binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in cytoplasm. Is expressed in brain; genitourinary system; heart; liver; and lung. Orthologous to human RUFY1 (RUN and FYVE domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 5.9), adrenal adult (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 30.57 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (50280113..50322101, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (50389286..50431274, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rabip4 plays a role in the endocytotic trafficking of Glut4 in 3T3-L1 adipocytes.
Title: The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.
Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
Title: The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH2 domain binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in early endosome to Golgi transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endosomal vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in endosomal vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
NOT located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RUN and FYVE domain-containing protein 1

Names: FYVE-finger containing protein; Rab4a interacting protein; rab4-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172557.3 → NP_766145.1 RUN and FYVE domain-containing protein 1

See identical proteins and their annotated locations for NP_766145.1

Status: VALIDATED

Source sequence(s)

AK046625, AK046633, BQ176179

Consensus CDS

CCDS24635.1

UniProtKB/Swiss-Prot

Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6

Related

ENSMUSP00000020643.4, ENSMUST00000020643.4

Conserved Domains (3) summary

cd15758
Location:638 → 708

FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins

pfam02759
Location:151 → 274

RUN; RUN domain

cl02073
Location:444 → 589

DUF3422; Protein of unknown function (DUF3422)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

50280113..50322101 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532841.5 → XP_006532904.1 RUN and FYVE domain-containing protein 1 isoform X1

Conserved Domains (3) summary

TIGR02168
Location:237 → 540

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd15758
Location:545 → 615

FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins

pfam02759
Location:58 → 179

RUN; RUN domain
XM_017314442.2 → XP_017169931.1 RUN and FYVE domain-containing protein 1 isoform X2

Conserved Domains (1) summary

pfam02759
Location:151 → 272

RUN; RUN domain