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Tead3 TEA domain family member 3 [ Mus musculus (house mouse) ]

Gene ID: 21678, updated on 27-Nov-2024

Summary

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Official Symbol
Tead3provided by MGI
Official Full Name
TEA domain family member 3provided by MGI
Primary source
MGI:MGI:109241
See related
Ensembl:ENSMUSG00000002249 AllianceGenome:MGI:109241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEF-5; DTEF-1; ETFR-1; TEAD-3; Tcf13r2
Summary
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in limb E14.5 (RPKM 22.9), bladder adult (RPKM 15.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Tead3 in Genome Data Viewer
Location:
17 A3.3; 17 14.66 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28550645..28569779, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28331671..28350805, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2476 Neighboring gene Fanconi anemia, complementation group E Neighboring gene ribosomal protein L10A Neighboring gene STARR-seq mESC enhancer starr_42209 Neighboring gene TUB like protein 1 Neighboring gene FK506 binding protein 5 Neighboring gene STARR-seq mESC enhancer starr_42210 Neighboring gene predicted gene, 22146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Jacquemin P, et al. J Biol Chem, 1997 May 16. PMID 9148898
  2. Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer. Jiang SW, et al. Mol Endocrinol, 1999 Jun. PMID 10379887
  3. Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes. Maeda T, et al. J Biol Chem, 2002 Jul 5. PMID 11986313
  4. A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns. Yasunami M, et al. Biochem Biophys Res Commun, 1996 Nov 12. PMID 8920920
  5. Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells. Cheng Y, et al. Gene Expr Patterns, 2023 Mar. PMID 36516960

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
    Title: Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
  2. Tead transcription factors differentially regulate cortical development.
    Title: Tead transcription factors differentially regulate cortical development.
  3. Experimental evidence for non-AUG translation initiation of human TEF-5. This non-AUG start site, AUA, is conserved in mouse.
    Title: Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer.
  4. DTEF-1 is a target for alpha(1)-adrenergic activation of the skeletal muscle alpha-actin gene in cardiac myocytes
    Title: Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in asymmetric neuroblast division ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
transcriptional enhancer factor TEF-5
Names
ETF-related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098226.3 → NP_001091696.2  transcriptional enhancer factor TEF-5 isoform 1

    See identical proteins and their annotated locations for NP_001091696.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). In variants 2 and 3, translation is initiated from an in-frame, downstream, non-AUG (AUA) start site, resulting in a shorter isoform (2).
    Source sequence(s)
    AK087649, CT025652, Y10027
    Consensus CDS
    CCDS50046.1
    UniProtKB/TrEMBL
    F8VPU0, Q8VCA7
    Related
    ENSMUSP00000110447.2, ENSMUST00000114799.8
    Conserved Domains (1) summary
    smart00426
    Location:56 → 123
    TEA; TEA domain

  2. NM_001204156.1 → NP_001191085.1  transcriptional enhancer factor TEF-5 isoform 2

    See identical proteins and their annotated locations for NP_001191085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a different 5' terminal exon and initiates translation from an in-frame, downstream, non-AUG (AUA) start site, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    CT025652
    Consensus CDS
    CCDS28577.3
    UniProtKB/Swiss-Prot
    O08516, O70623, P70209, P70210
    UniProtKB/TrEMBL
    F6TTJ9
    Related
    ENSMUSP00000118582.3, ENSMUST00000154873.9
    Conserved Domains (1) summary
    smart00426
    Location:30 → 97
    TEA; TEA domain

  3. NM_011566.4 → NP_035696.3  transcriptional enhancer factor TEF-5 isoform 2

    See identical proteins and their annotated locations for NP_035696.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 5' terminal exon and initiates translation from an in-frame, downstream, non-AUG (AUA) start site, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    CF617964, CT025652, Y10027
    Consensus CDS
    CCDS28577.3
    UniProtKB/Swiss-Prot
    O08516, O70623, P70209, P70210
    UniProtKB/TrEMBL
    F6TTJ9
    Related
    ENSMUSP00000115443.3, ENSMUST00000156862.3
    Conserved Domains (1) summary
    smart00426
    Location:30 → 97
    TEA; TEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28550645..28569779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70210.2 GenPept UniProtKB/Swiss-Prot:P70210

Gene LinkOut

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