Tead4 TEA domain family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tead4provided by MGI
Official Full Name: TEA domain family member 4provided by MGI
Primary source: MGI:MGI:106907
See related: Ensembl:ENSMUSG00000030353 AllianceGenome:MGI:106907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tef3; Tefr; Etfr2; FR-19; Rtef1; TEF-3; Tefr1; ETFR-2; TEAD-4; Tefr1a; Tcf13r1
Summary: This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta adult (RPKM 4.9), lung adult (RPKM 4.8) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 62.92 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128204106..128277776, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128227143..128300813, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.
Title: Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.
TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle.
Title: TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle.
TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.
Title: TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.
Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
Title: Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
Loss of Anks6 leads to YAP deficiency and liver abnormalities.
Title: Loss of Anks6 leads to YAP deficiency and liver abnormalities.
Developmental clock and mechanism of de novo polarization of the mouse embryo.
Title: Developmental clock and mechanism of de novo polarization of the mouse embryo.
These results present evidence for direct transcriptional repression of Sox2 by YAP1, WWTR1 and TEAD4.
Title: TEAD4, YAP1 and WWTR1 prevent the premature onset of pluripotency prior to the 16-cell stage.
We show that YAP1-TEAD4 transcription factor-mediated transcription is essential for Z-decay in mouse embryos and that TEAD4-triggered zygotic expression of terminal uridylyltransferases TUT4 and TUT7 and mRNA 3'-oligouridylation direct Z-decay.
Title: Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse.
VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CtBP2, and this TEAD4-VGLL4-CtBP2 ternary complex dynamically existed at the early stage of adipogenesis.
Title: The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex.
Schwann cell-specific deletion of either Hdac3 or Tead4 in mice resulted in an elevation of myelin thickness in sciatic nerves. Thus, our findings identify the HDAC3-TEAD4 network as a dual-function switch of cell-intrinsic inhibitory machinery that counters myelinogenic signals and maintains peripheral myelin homeostasis
Title: A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D87966 (e-PCR)
- UniSTS:179469

37.MMHAP65FLE4.seq (e-PCR)
- UniSTS:124241

Tead4 (e-PCR), detects polymorphism
- UniSTS:144599

L26343 (e-PCR)
- UniSTS:124888

Tead4 (e-PCR), detects polymorphism
- UniSTS:548086

px-42h6 (e-PCR)
- UniSTS:257787

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophectodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcriptional enhancer factor TEF-3

Names: ETF-related factor-2; FGF-regulated 19; RTEF-1; TEF-1-related factor 1; TEF-1-related factor FR-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080979.1 → NP_001074448.2 transcriptional enhancer factor TEF-3 isoform b

See identical proteins and their annotated locations for NP_001074448.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (b, also known as ETFR-2b) that lacks an internal segment, compared to isoform a. It also initiates translation from a non-AUG (AUU) codon.

Source sequence(s)

AB221623, D87965, D87966, X94441

Consensus CDS

CCDS39645.1

UniProtKB/TrEMBL

A0A0R4J1U4

Related

ENSMUSP00000107784.3, ENSMUST00000112157.4

Conserved Domains (1) summary

smart00426
Location:31 → 98

TEA; TEA domain
NM_011567.2 → NP_035697.3 transcriptional enhancer factor TEF-3 isoform a

See identical proteins and their annotated locations for NP_035697.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a, also known as ETFR-2a), and initiates translation from a non-AUG (AUU) codon.

Source sequence(s)

AB221623, BC130257, D87965, D87966

Consensus CDS

CCDS39646.1

UniProtKB/Swiss-Prot

A2BDD5, P70282, Q61174, Q61175, Q62296, Q62298

UniProtKB/TrEMBL

A0A0R4IZY5

Related

ENSMUSP00000006311.7, ENSMUST00000006311.13

Conserved Domains (1) summary

smart00426
Location:31 → 98

TEA; TEA domain