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Tmem11 transmembrane protein 11 [ Mus musculus (house mouse) ]

Gene ID: 216821, updated on 27-Nov-2024

Summary

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Official Symbol
Tmem11provided by MGI
Official Full Name
transmembrane protein 11provided by MGI
Primary source
MGI:MGI:2144726
See related
Ensembl:ENSMUSG00000043284 AllianceGenome:MGI:2144726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730466P16Rik
Summary
Predicted to be involved in inner mitochondrial membrane organization. Located in mitochondrion. Is expressed in cap mesenchyme and renal interstitium. Orthologous to human TMEM11 (transmembrane protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 40.7), adrenal adult (RPKM 32.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem11 in Genome Data Viewer
Location:
11 B2; 11 37.9 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60755278..60769864, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60864452..60879038, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoserine aminotransferase 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8411 Neighboring gene dehydrogenase/reductase 7B Neighboring gene STARR-positive B cell enhancer ABC_E10679 Neighboring gene STARR-seq mESC enhancer starr_29661 Neighboring gene predicted gene, 26534 Neighboring gene N-acetyltransferase domain containing 1 Neighboring gene predicted gene, 39830

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA. Chen XZ, et al. Cell Death Differ, 2023 Jul. PMID 37286744, Free PMC Article
  2. Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike. Yan J, et al. Am J Hum Genet, 2007 Mar. PMID 17273973, Free PMC Article
  3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m[7]G methylation of ATF5 mRNA.
    Title: TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 11, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168507.1 → NP_001161979.1  transmembrane protein 11, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL596215, CX211768
    Consensus CDS
    CCDS48815.1
    UniProtKB/TrEMBL
    E9Q933
    Related
    ENSMUSP00000128654.2, ENSMUST00000168218.8
    Conserved Domains (1) summary
    pfam14972
    Location:12 → 174
    Mito_morph_reg; Mitochondrial morphogenesis regulator

  2. NM_173453.3 → NP_775655.1  transmembrane protein 11, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_775655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI835409, AK077600, AL596215
    Consensus CDS
    CCDS24801.1
    UniProtKB/Swiss-Prot
    Q5NCT6, Q8BK08
    Related
    ENSMUSP00000059494.6, ENSMUST00000062677.12
    Conserved Domains (1) summary
    pfam14972
    Location:26 → 188
    Mito_morph_reg; Mitochondrial morphogenesis regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    60755278..60769864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BK08.1 GenPept UniProtKB/Swiss-Prot:Q8BK08

Gene LinkOut

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