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Prss39 serine protease 39 [ Mus musculus (house mouse) ]

Gene ID: 21755, updated on 27-Nov-2024

Summary

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Official Symbol
Prss39provided by MGI
Official Full Name
serine protease 39provided by MGI
Primary source
MGI:MGI:1270856
See related
Ensembl:ENSMUSG00000026125 AllianceGenome:MGI:1270856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tesp1
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 299.9) See more
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Genomic context

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See Prss39 in Genome Data Viewer
Location:
1 B; 1 13.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34537493..34542143)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34498412..34503062)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene RIKEN cDNA 4930568A12 gene Neighboring gene predicted gene 28417 Neighboring gene predicted gene, 32566 Neighboring gene serine protease 40 Neighboring gene predicted gene 28419 Neighboring gene cryptic, EGF-CFC family member 1 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome. Ramachandran SS, et al. Mol Hum Reprod, 2021 Sep 29. PMID 34524424
  2. Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome. Kohno N, et al. Biochem Biophys Res Commun, 1998 Apr 28. PMID 9588171
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome.
    Title: A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC144580, MGC144581

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inactive serine protease 39
Names
inactive testicular serine protease 1
protease, serine 39
testicular serine protease 1
NP_001347784.1
NP_033381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360855.1 → NP_001347784.1  inactive serine protease 39 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC106841
    Conserved Domains (1) summary
    cd00190
    Location:3 → 173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_009355.3 → NP_033381.1  inactive serine protease 39 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC106841, BC049616, BY716157
    Consensus CDS
    CCDS14868.1
    UniProtKB/Swiss-Prot
    O70169, Q80YD5
    Related
    ENSMUSP00000027299.4, ENSMUST00000027299.10
    Conserved Domains (2) summary
    smart00020
    Location:67 → 307
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:68 → 310
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34537493..34542143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70169.1 GenPept UniProtKB/Swiss-Prot:O70169

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