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Prss40 serine protease 40 [ Mus musculus (house mouse) ]

Gene ID: 21756, updated on 27-Nov-2024

Summary

Official Symbol
Prss40provided by MGI
Official Full Name
serine protease 40provided by MGI
Primary source
MGI:MGI:1270857
See related
Ensembl:ENSMUSG00000037529 AllianceGenome:MGI:1270857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tesp2
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle and extracellular region. Predicted to be active in extracellular space. Is expressed in bone marrow; brain; genitourinary system; and submandibular gland. Orthologous to human PRSS40A (serine protease 40A (pseudogene)) and PRSS40B (serine protease 40B (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 22.9) See more
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Genomic context

See Prss40 in Genome Data Viewer
Location:
1 B; 1 13.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34575529..34600099, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34536448..34561004, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930568A12 gene Neighboring gene predicted gene, 32566 Neighboring gene serine protease 39 Neighboring gene predicted gene 28419 Neighboring gene cryptic, EGF-CFC family member 1 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 pseudogene Neighboring gene APC membrane recruitment 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine protease 40
Names
protease, serine 40
testicular serine protease 2
NP_033382.2
XP_006495919.1
XP_006495920.1
XP_006495921.1
XP_006495922.1
XP_006495923.1
XP_006495924.1
XP_006495925.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009356.2NP_033382.2  serine protease 40 precursor

    See identical proteins and their annotated locations for NP_033382.2

    Status: VALIDATED

    Source sequence(s)
    AC106841
    Consensus CDS
    CCDS14870.1
    UniProtKB/Swiss-Prot
    A6H6T1, E9QL09, O70170
    Related
    ENSMUSP00000045118.8, ENSMUST00000047840.9
    Conserved Domains (2) summary
    smart00020
    Location:68308
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:69311
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34575529..34600099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495857.4XP_006495920.1  serine protease 40 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:69260
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006495862.4XP_006495925.1  serine protease 40 isoform X6

    UniProtKB/TrEMBL
    Q3V0T7
    Conserved Domains (1) summary
    cl21584
    Location:2141
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_006495858.5XP_006495921.1  serine protease 40 isoform X3

    Conserved Domains (1) summary
    cd00190
    Location:69263
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_006495856.5XP_006495919.1  serine protease 40 isoform X1

    Conserved Domains (1) summary
    cd00190
    Location:69260
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_006495859.5XP_006495922.1  serine protease 40 isoform X4

    Conserved Domains (1) summary
    cd00190
    Location:69262
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. XM_006495861.2XP_006495924.1  serine protease 40 isoform X5

    See identical proteins and their annotated locations for XP_006495924.1

    Conserved Domains (1) summary
    cd00190
    Location:2189
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  7. XM_006495860.2XP_006495923.1  serine protease 40 isoform X5

    See identical proteins and their annotated locations for XP_006495923.1

    Conserved Domains (1) summary
    cd00190
    Location:2189
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...