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Lhfpl2 lipoma HMGIC fusion partner-like 2 [ Mus musculus (house mouse) ]

Gene ID: 218454, updated on 27-Nov-2024

Summary

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Official Symbol
Lhfpl2provided by MGI
Official Full Name
lipoma HMGIC fusion partner-like 2provided by MGI
Primary source
MGI:MGI:2145236
See related
Ensembl:ENSMUSG00000045312 AllianceGenome:MGI:2145236
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
vgim; mKIAA0206; 6030465B15
Summary
Involved in development of primary female sexual characteristics; development of primary male sexual characteristics; and positive regulation of fertilization. Predicted to be active in membrane. Is expressed in several structures, including central nervous system; hemolymphoid system gland; liver; reproductive system; and tail unsegmented mesenchyme. Orthologous to human LHFPL2 (LHFPL tetraspan subfamily member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 19.7), limb E14.5 (RPKM 15.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Lhfpl2 in Genome Data Viewer
Location:
13 C3; 13 49.03 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (94193659..94331918)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (94057152..94195410)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35297 Neighboring gene predicted gene, 24737 Neighboring gene STARR-seq mESC enhancer starr_35299 Neighboring gene STARR-seq mESC enhancer starr_35300 Neighboring gene cytochrome c, pseudogene 3 Neighboring gene predicted gene, 57596 Neighboring gene secretory carrier membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_35303 Neighboring gene predicted gene, 32089

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel function of LHFPL2 in female and male distal reproductive tract development. Zhao F, et al. Sci Rep, 2016 Mar 11. PMID 26964900, Free PMC Article
  2. Mutation discovery in mice by whole exome sequencing. Fairfield H, et al. Genome Biol, 2011 Sep 14. PMID 21917142, Free PMC Article
  3. Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Chal J, et al. Development, 2018 Mar 19. PMID 29555813
  4. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Fairfield H, et al. Genome Res, 2015 Jul. PMID 25917818, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Spontaneous (1) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in development of primary female sexual characteristics IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in development of primary male sexual characteristics IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LHFPL tetraspan subfamily member 2 protein
Names
lipoma HMGIC fusion partner-like 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172589.2 → NP_766177.1  LHFPL tetraspan subfamily member 2 protein

    See identical proteins and their annotated locations for NP_766177.1

    Status: PROVISIONAL

    Source sequence(s)
    AK087506
    Consensus CDS
    CCDS26692.1
    UniProtKB/Swiss-Prot
    Q8BGA2
    Related
    ENSMUSP00000062239.2, ENSMUST00000054274.8
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    94193659..94331918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247231.2 → XP_030103091.1  LHFPL tetraspan subfamily member 2 protein isoform X2

  2. XM_011244639.4 → XP_011242941.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    See identical proteins and their annotated locations for XP_011242941.1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  3. XM_036158012.1 → XP_036013905.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  4. XM_011244640.3 → XP_011242942.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    See identical proteins and their annotated locations for XP_011242942.1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  5. XM_036158013.1 → XP_036013906.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  6. XM_036158014.1 → XP_036013907.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  7. XM_011244641.4 → XP_011242943.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    See identical proteins and their annotated locations for XP_011242943.1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  8. XM_011244642.4 → XP_011242944.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    See identical proteins and their annotated locations for XP_011242944.1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  9. XM_011244643.4 → XP_011242945.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    See identical proteins and their annotated locations for XP_011242945.1

    UniProtKB/Swiss-Prot
    Q8BGA2
    Related
    ENSMUSP00000113468.2, ENSMUST00000121618.2
    Conserved Domains (1) summary
    cl21598
    Location:9 → 198
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGA2.1 GenPept UniProtKB/Swiss-Prot:Q8BGA2

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