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BPTF bromodomain PHD finger transcription factor [ Homo sapiens (human) ]

Gene ID: 2186, updated on 27-Nov-2024

Summary

Official Symbol
BPTFprovided by HGNC
Official Full Name
bromodomain PHD finger transcription factorprovided by HGNC
Primary source
HGNC:HGNC:3581
See related
Ensembl:ENSG00000171634 MIM:601819; AllianceGenome:HGNC:3581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAC1; FALZ; NEDDFL; NURF301
Summary
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 8.1) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See BPTF in Genome Data Viewer
Location:
17q24.2
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (67825503..67984378)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (68700733..68859565)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65821619..65980494)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7199 Neighboring gene ribosomal protein SA pseudogene 67 Neighboring gene ribosomal protein L17 pseudogene 41 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:65820867-65821564 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:65821565-65822260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12632 Neighboring gene NANOG hESC enhancer GRCh37_chr17:65827101-65827602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12633 Neighboring gene Sharpr-MPRA regulatory region 4989 Neighboring gene RNA, 7SL, cytoplasmic 622, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8883 Neighboring gene chromosome 17 open reading frame 58 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66016003-66016576 Neighboring gene tRNA-Arg (anticodon CCG) 2-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies
MedGen: C4540327 OMIM: 617755 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2022-07-12)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2022-07-12)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.
EBI GWAS Catalog
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NURF complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NURF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NURF complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nucleosome-remodeling factor subunit BPTF
Names
bromodomain and PHD domain transcription factor
bromodomain and PHD finger-containing transcription factor
fetal Alz-50 clone 1 protein
fetal Alz-50 reactive clone 1
fetal Alzheimer antigen
nucleosome remodeling factor, large subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052828.1 RefSeqGene

    Range
    4987..163862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004459.7NP_004450.3  nucleosome-remodeling factor subunit BPTF isoform 2

    See identical proteins and their annotated locations for NP_004450.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains two additional in-frame exons in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB032251, AC006534, AC134407, AK022570, AK025776, AL833375, AY282495, BC037422
    UniProtKB/TrEMBL
    E7ETD6
    Related
    ENSP00000388405.3, ENST00000424123.7
    Conserved Domains (6) summary
    cd05509
    Location:27882888
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:21632583
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27262772
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  2. NM_182641.4NP_872579.2  nucleosome-remodeling factor subunit BPTF isoform 1

    See identical proteins and their annotated locations for NP_872579.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB032251, AC006534, AC134407, AK022570, AK025776, AY282495, BC037422, CV809604
    Consensus CDS
    CCDS11673.1
    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Related
    ENSP00000307208.6, ENST00000306378.11
    Conserved Domains (6) summary
    cd05509
    Location:28052905
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:20372418
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27432789
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    67825503..67984378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257150.4XP_005257207.1  nucleosome-remodeling factor subunit BPTF isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7Q1, J3QQK4
    Related
    ENSP00000463776.2, ENST00000582467.2
    Conserved Domains (7) summary
    cd05509
    Location:30433143
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27422972
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22172598
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29813027
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  2. XM_005257154.4XP_005257211.1  nucleosome-remodeling factor subunit BPTF isoform X6

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (6) summary
    cd05509
    Location:29853085
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:22172598
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29232969
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  3. XM_005257159.3XP_005257216.1  nucleosome-remodeling factor subunit BPTF isoform X20

    UniProtKB/TrEMBL
    E9PE19
    Conserved Domains (7) summary
    cd05509
    Location:29003000
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:25992829
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22172637
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28382884
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  4. XM_005257161.4XP_005257218.1  nucleosome-remodeling factor subunit BPTF isoform X27

    UniProtKB/TrEMBL
    E7ETD6
    Conserved Domains (6) summary
    cd05509
    Location:28422942
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:22172637
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27802826
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  5. XM_005257153.4XP_005257210.1  nucleosome-remodeling factor subunit BPTF isoform X5

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Related
    ENSP00000496182.2, ENST00000644067.1
    Conserved Domains (7) summary
    cd05509
    Location:29893089
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26882918
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21632544
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29272973
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  6. XM_047435597.1XP_047291553.1  nucleosome-remodeling factor subunit BPTF isoform X13

    UniProtKB/Swiss-Prot
    Q12830, Q6NX67, Q7Z7D6, Q9UIG2
    Related
    ENSP00000315454.4, ENST00000321892.8
  7. XM_005257160.3XP_005257217.1  nucleosome-remodeling factor subunit BPTF isoform X26

    UniProtKB/TrEMBL
    E9PE19
    Related
    ENSP00000343837.5, ENST00000342579.8
    Conserved Domains (7) summary
    cd05509
    Location:28462946
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:25452775
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21632583
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27842830
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  8. XM_005257151.4XP_005257208.1  nucleosome-remodeling factor subunit BPTF isoform X3

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:30423142
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27412971
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22162597
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29803026
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  9. XM_011524520.3XP_011522822.1  nucleosome-remodeling factor subunit BPTF isoform X2

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:30423142
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27412971
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22162597
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29803026
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  10. XM_005257155.4XP_005257212.1  nucleosome-remodeling factor subunit BPTF isoform X7

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:29803080
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26792909
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21542535
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29182964
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  11. XM_047435605.1XP_047291561.1  nucleosome-remodeling factor subunit BPTF isoform X28

  12. XM_047435598.1XP_047291554.1  nucleosome-remodeling factor subunit BPTF isoform X14

  13. XM_047435602.1XP_047291558.1  nucleosome-remodeling factor subunit BPTF isoform X22

  14. XM_047435609.1XP_047291565.1  nucleosome-remodeling factor subunit BPTF isoform X32

  15. XM_005257157.4XP_005257214.1  nucleosome-remodeling factor subunit BPTF isoform X10

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:29793079
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26782908
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21532534
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29172963
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  16. XM_047435600.1XP_047291556.1  nucleosome-remodeling factor subunit BPTF isoform X16

  17. XM_005257156.4XP_005257213.1  nucleosome-remodeling factor subunit BPTF isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:29803080
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26792909
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21542535
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29182964
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  18. XM_047435599.1XP_047291555.1  nucleosome-remodeling factor subunit BPTF isoform X15

  19. XM_047435603.1XP_047291559.1  nucleosome-remodeling factor subunit BPTF isoform X23

  20. XM_047435610.1XP_047291566.1  nucleosome-remodeling factor subunit BPTF isoform X33

  21. XM_047435614.1XP_047291570.1  nucleosome-remodeling factor subunit BPTF isoform X37

  22. XM_024450646.2XP_024306414.1  nucleosome-remodeling factor subunit BPTF isoform X11

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (9) summary
    cd05509
    Location:29793079
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:240299
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29172963
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam09606
    Location:21212496
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15612
    Location:344381
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:456524
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl02572
    Location:13461605
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cl26267
    Location:26782908
    ING; Inhibitor of growth proteins N-terminal histone-binding
  23. XM_047435611.1XP_047291567.1  nucleosome-remodeling factor subunit BPTF isoform X34

  24. XM_005257158.4XP_005257215.1  nucleosome-remodeling factor subunit BPTF isoform X18

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:29173017
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26162846
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:20912472
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28552901
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  25. XM_047435613.1XP_047291569.1  nucleosome-remodeling factor subunit BPTF isoform X36

  26. XM_047435604.1XP_047291560.1  nucleosome-remodeling factor subunit BPTF isoform X24

  27. XM_047435615.1XP_047291571.1  nucleosome-remodeling factor subunit BPTF isoform X38

  28. XM_047435617.1XP_047291573.1  nucleosome-remodeling factor subunit BPTF isoform X40

  29. XM_011524522.3XP_011522824.1  nucleosome-remodeling factor subunit BPTF isoform X19

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:29163016
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26152845
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:20902471
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28542900
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  30. XM_011524523.3XP_011522825.1  nucleosome-remodeling factor subunit BPTF isoform X25

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:28622962
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:25612791
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:20362417
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28002846
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  31. XM_011524525.3XP_011522827.1  nucleosome-remodeling factor subunit BPTF isoform X47

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (6) summary
    cd05509
    Location:28042904
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:20362417
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27422788
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  32. XM_047435616.1XP_047291572.1  nucleosome-remodeling factor subunit BPTF isoform X39

  33. XM_011524526.3XP_011522828.1  nucleosome-remodeling factor subunit BPTF isoform X48

    UniProtKB/TrEMBL
    E7ETD6
    Conserved Domains (6) summary
    cd05509
    Location:26612761
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:20362456
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:25992645
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  34. XM_017024353.3XP_016879842.1  nucleosome-remodeling factor subunit BPTF isoform X12

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
  35. XM_047435607.1XP_047291563.1  nucleosome-remodeling factor subunit BPTF isoform X30

  36. XM_047435601.1XP_047291557.1  nucleosome-remodeling factor subunit BPTF isoform X17

  37. XM_047435612.1XP_047291568.1  nucleosome-remodeling factor subunit BPTF isoform X35

  38. XM_047435608.1XP_047291564.1  nucleosome-remodeling factor subunit BPTF isoform X31

  39. XM_005257152.4XP_005257209.1  nucleosome-remodeling factor subunit BPTF isoform X4

    UniProtKB/TrEMBL
    A0A2R8Y7Q1
    Conserved Domains (7) summary
    cd05509
    Location:30433143
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27422972
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22172598
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29813027
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  40. XM_024450647.2XP_024306415.1  nucleosome-remodeling factor subunit BPTF isoform X21

    UniProtKB/TrEMBL
    E9PE19
    Conserved Domains (9) summary
    cd05509
    Location:29003000
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:240299
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28382884
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam09606
    Location:21752520
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15612
    Location:344381
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:456524
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl02572
    Location:14101669
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cl26267
    Location:25992829
    ING; Inhibitor of growth proteins N-terminal histone-binding
  41. XM_047435596.1XP_047291552.1  nucleosome-remodeling factor subunit BPTF isoform X9

  42. XM_047435606.1XP_047291562.1  nucleosome-remodeling factor subunit BPTF isoform X29

  43. XM_047435618.1XP_047291574.1  nucleosome-remodeling factor subunit BPTF isoform X41

  44. XM_047435619.1XP_047291575.1  nucleosome-remodeling factor subunit BPTF isoform X42

    Related
    ENSP00000440854.2, ENST00000544778.6
  45. XM_017024354.3XP_016879843.1  nucleosome-remodeling factor subunit BPTF isoform X43

  46. XM_011524524.4XP_011522826.1  nucleosome-remodeling factor subunit BPTF isoform X44

    Conserved Domains (4) summary
    cd05509
    Location:20732173
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:17722002
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:12471628
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15560
    Location:20112057
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
  47. XM_047435620.1XP_047291576.1  nucleosome-remodeling factor subunit BPTF isoform X45

  48. XM_047435621.1XP_047291577.1  nucleosome-remodeling factor subunit BPTF isoform X46

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    68700733..68859565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315429.1XP_054171404.1  nucleosome-remodeling factor subunit BPTF isoform X1

    UniProtKB/TrEMBL
    J3QQK4
  2. XM_054315434.1XP_054171409.1  nucleosome-remodeling factor subunit BPTF isoform X6

  3. XM_054315448.1XP_054171423.1  nucleosome-remodeling factor subunit BPTF isoform X20

  4. XM_054315455.1XP_054171430.1  nucleosome-remodeling factor subunit BPTF isoform X27

  5. XM_054315433.1XP_054171408.1  nucleosome-remodeling factor subunit BPTF isoform X5

  6. XM_054315441.1XP_054171416.1  nucleosome-remodeling factor subunit BPTF isoform X13

    UniProtKB/Swiss-Prot
    Q12830, Q6NX67, Q7Z7D6, Q9UIG2
  7. XM_054315454.1XP_054171429.1  nucleosome-remodeling factor subunit BPTF isoform X26

  8. XM_054315431.1XP_054171406.1  nucleosome-remodeling factor subunit BPTF isoform X3

  9. XM_054315430.1XP_054171405.1  nucleosome-remodeling factor subunit BPTF isoform X2

  10. XM_054315435.1XP_054171410.1  nucleosome-remodeling factor subunit BPTF isoform X7

  11. XM_054315456.1XP_054171431.1  nucleosome-remodeling factor subunit BPTF isoform X28

  12. XM_054315442.1XP_054171417.1  nucleosome-remodeling factor subunit BPTF isoform X14

  13. XM_054315450.1XP_054171425.1  nucleosome-remodeling factor subunit BPTF isoform X22

  14. XM_054315460.1XP_054171435.1  nucleosome-remodeling factor subunit BPTF isoform X32

  15. XM_054315438.1XP_054171413.1  nucleosome-remodeling factor subunit BPTF isoform X10

  16. XM_054315444.1XP_054171419.1  nucleosome-remodeling factor subunit BPTF isoform X16

  17. XM_054315436.1XP_054171411.1  nucleosome-remodeling factor subunit BPTF isoform X8

  18. XM_054315443.1XP_054171418.1  nucleosome-remodeling factor subunit BPTF isoform X15

  19. XM_054315451.1XP_054171426.1  nucleosome-remodeling factor subunit BPTF isoform X23

  20. XM_054315461.1XP_054171436.1  nucleosome-remodeling factor subunit BPTF isoform X33

  21. XM_054315465.1XP_054171440.1  nucleosome-remodeling factor subunit BPTF isoform X37

  22. XM_054315439.1XP_054171414.1  nucleosome-remodeling factor subunit BPTF isoform X11

  23. XM_054315462.1XP_054171437.1  nucleosome-remodeling factor subunit BPTF isoform X34

  24. XM_054315446.1XP_054171421.1  nucleosome-remodeling factor subunit BPTF isoform X18

  25. XM_054315464.1XP_054171439.1  nucleosome-remodeling factor subunit BPTF isoform X36

  26. XM_054315452.1XP_054171427.1  nucleosome-remodeling factor subunit BPTF isoform X24

  27. XM_054315466.1XP_054171441.1  nucleosome-remodeling factor subunit BPTF isoform X38

  28. XM_054315468.1XP_054171443.1  nucleosome-remodeling factor subunit BPTF isoform X40

  29. XM_054315447.1XP_054171422.1  nucleosome-remodeling factor subunit BPTF isoform X19

  30. XM_054315453.1XP_054171428.1  nucleosome-remodeling factor subunit BPTF isoform X25

  31. XM_054315475.1XP_054171450.1  nucleosome-remodeling factor subunit BPTF isoform X47

  32. XM_054315467.1XP_054171442.1  nucleosome-remodeling factor subunit BPTF isoform X39

  33. XM_054315476.1XP_054171451.1  nucleosome-remodeling factor subunit BPTF isoform X48

  34. XM_054315440.1XP_054171415.1  nucleosome-remodeling factor subunit BPTF isoform X12

  35. XM_054315458.1XP_054171433.1  nucleosome-remodeling factor subunit BPTF isoform X30

  36. XM_054315445.1XP_054171420.1  nucleosome-remodeling factor subunit BPTF isoform X17

  37. XM_054315463.1XP_054171438.1  nucleosome-remodeling factor subunit BPTF isoform X35

  38. XM_054315459.1XP_054171434.1  nucleosome-remodeling factor subunit BPTF isoform X31

  39. XM_054315432.1XP_054171407.1  nucleosome-remodeling factor subunit BPTF isoform X4

  40. XM_054315449.1XP_054171424.1  nucleosome-remodeling factor subunit BPTF isoform X21

  41. XM_054315437.1XP_054171412.1  nucleosome-remodeling factor subunit BPTF isoform X9

  42. XM_054315457.1XP_054171432.1  nucleosome-remodeling factor subunit BPTF isoform X29

  43. XM_054315469.1XP_054171444.1  nucleosome-remodeling factor subunit BPTF isoform X41

  44. XM_054315470.1XP_054171445.1  nucleosome-remodeling factor subunit BPTF isoform X42

  45. XM_054315471.1XP_054171446.1  nucleosome-remodeling factor subunit BPTF isoform X43

  46. XM_054315472.1XP_054171447.1  nucleosome-remodeling factor subunit BPTF isoform X44

  47. XM_054315473.1XP_054171448.1  nucleosome-remodeling factor subunit BPTF isoform X45

  48. XM_054315474.1XP_054171449.1  nucleosome-remodeling factor subunit BPTF isoform X46