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Pxk PX domain containing serine/threonine kinase [ Mus musculus (house mouse) ]

Gene ID: 218699, updated on 4-Jan-2025

Summary

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Official Symbol
Pxkprovided by MGI
Official Full Name
PX domain containing serine/threonine kinaseprovided by MGI
Primary source
MGI:MGI:1289230
See related
Ensembl:ENSMUSG00000033885 AllianceGenome:MGI:1289230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slob; Monaka; D14Ertd813e; C230080L11Rik
Summary
Predicted to enable several functions, including ATP binding activity; actin binding activity; and phosphatidylinositol binding activity. Involved in modulation of chemical synaptic transmission; negative regulation of ATP-dependent activity; and negative regulation of monoatomic ion transport. Located in cytoplasm and plasma membrane. Part of protein-containing complex. Is expressed in brain and spinal cord. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in spleen adult (RPKM 18.0), placenta adult (RPKM 17.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pxk in Genome Data Viewer
Location:
14 A1; 14 4.7 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14304656..14371593, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8098180..8165117)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53823 Neighboring gene STARR-seq mESC enhancer starr_35863 Neighboring gene pyruvate dehydrogenase (lipoamide) beta Neighboring gene STARR-positive B cell enhancer mm9_chr14:8946918-8947218 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene ribonuclease P 14 subunit Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene STARR-seq mESC enhancer starr_35858 Neighboring gene STARR-seq mESC enhancer starr_35854 Neighboring gene abhydrolase domain containing 6 Neighboring gene predicted gene, 30244

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. Mao H, et al. J Neurosci, 2005 Aug 31. PMID 16135750, Free PMC Article
  2. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
  3. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
  4. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Licatalosi DD, et al. Genes Dev, 2012 Jul 15. PMID 22802532, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of monoatomic ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PX domain-containing protein kinase-like protein
Names
modulator of Na,K-ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360313.1 → NP_001347242.1  PX domain-containing protein kinase-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK150660, AK153067, AW455875
    Consensus CDS
    CCDS88565.1
    UniProtKB/TrEMBL
    A0A2C9F2B5
    Related
    ENSMUSP00000035265.9, ENSMUST00000036682.9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 482
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  2. NM_001360314.1 → NP_001347243.1  PX domain-containing protein kinase-like protein short isoform

    Status: VALIDATED

    Source sequence(s)
    AK150337, AK150660, AK153067, AW455875, CT573024
    Consensus CDS
    CCDS36799.1
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  3. NM_001360315.1 → NP_001347244.1  PX domain-containing protein kinase-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK150660, AK153067, AW455875, BM945330, CT573024
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 482
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  4. NM_001360316.1 → NP_001347245.1  PX domain-containing protein kinase-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK150337, AK150660, AK153067, AW455875, CT573024

  5. NM_145458.4 → NP_663433.2  PX domain-containing protein kinase-like protein long isoform

    See identical proteins and their annotated locations for NP_663433.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (L) encodes the longest isoform.
    Source sequence(s)
    AK150337, AK150660, AK153067, AW455875
    Consensus CDS
    CCDS26810.1
    UniProtKB/Swiss-Prot
    Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q8BX57, Q91WB6
    Related
    ENSMUSP00000152987.2, ENSMUST00000225653.2
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  6. NM_178279.3 → NP_840063.1  PX domain-containing protein kinase-like protein short isoform

    See identical proteins and their annotated locations for NP_840063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (S) uses an alternate splice site in the 3' coding region, compared to variant L. The resulting protein is shorter and has a distinct C-terminus, when compared to the longer isoform.
    Source sequence(s)
    AK150660, AK153067, AW455875, BM945330, CT573024
    Consensus CDS
    CCDS36799.1
    UniProtKB/Swiss-Prot
    Q8BX57
    Related
    ENSMUSP00000108309.3, ENSMUST00000112689.9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    14304656..14371593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517982.3 → XP_006518045.1  PX domain-containing protein kinase-like protein isoform X7

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  2. XM_006517977.4 → XP_006518040.1  PX domain-containing protein kinase-like protein isoform X2

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  3. XM_030247724.1 → XP_030103584.1  PX domain-containing protein kinase-like protein isoform X5

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  4. XM_006517980.3 → XP_006518043.1  PX domain-containing protein kinase-like protein isoform X6

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  5. XM_006517975.4 → XP_006518038.1  PX domain-containing protein kinase-like protein isoform X1

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  6. XM_006517978.4 → XP_006518041.1  PX domain-containing protein kinase-like protein isoform X4

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  7. XM_036158542.1 → XP_036014435.1  PX domain-containing protein kinase-like protein isoform X9

    Conserved Domains (3) summary
    cd22062
    Location:465 → 495
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  8. XM_036158540.1 → XP_036014433.1  PX domain-containing protein kinase-like protein isoform X8

    Conserved Domains (3) summary
    cd22062
    Location:466 → 496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  9. XM_036158541.1 → XP_036014434.1  PX domain-containing protein kinase-like protein isoform X8

    Conserved Domains (3) summary
    cd22062
    Location:466 → 496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  10. XM_030247727.1 → XP_030103587.1  PX domain-containing protein kinase-like protein isoform X9

    Conserved Domains (3) summary
    cd22062
    Location:465 → 495
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  11. XM_030247728.1 → XP_030103588.1  PX domain-containing protein kinase-like protein isoform X10

    Conserved Domains (2) summary
    cd00180
    Location:115 → 262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  12. XM_006517984.2 → XP_006518047.1  PX domain-containing protein kinase-like protein isoform X8

    See identical proteins and their annotated locations for XP_006518047.1

    Conserved Domains (3) summary
    cd22062
    Location:466 → 496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  13. XM_030247726.1 → XP_030103586.1  PX domain-containing protein kinase-like protein isoform X9

    Conserved Domains (3) summary
    cd22062
    Location:465 → 495
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  14. XM_006517985.2 → XP_006518048.1  PX domain-containing protein kinase-like protein isoform X8

    See identical proteins and their annotated locations for XP_006518048.1

    Conserved Domains (3) summary
    cd22062
    Location:466 → 496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  15. XM_017315951.2 → XP_017171440.1  PX domain-containing protein kinase-like protein isoform X6

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  16. XM_017315949.2 → XP_017171438.1  PX domain-containing protein kinase-like protein isoform X3

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

RNA

  1. XR_874027.3 RNA Sequence

  2. XR_001781106.2 RNA Sequence

  3. XR_004938378.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX57.2 GenPept UniProtKB/Swiss-Prot:Q8BX57

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