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Tnfrsf17 tumor necrosis factor receptor superfamily, member 17 [ Mus musculus (house mouse) ]

Gene ID: 21935, updated on 27-Nov-2024

Summary

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Official Symbol
Tnfrsf17provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 17provided by MGI
Primary source
MGI:MGI:1343050
See related
Ensembl:ENSMUSG00000022496 AllianceGenome:MGI:1343050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BCM; BCMA; Tnfrsf13; Tnfrsf13a
Summary
Predicted to enable signaling receptor activity. Acts upstream of or within lymphocyte homeostasis. Predicted to be located in membrane. Is expressed in several structures, including hemolymphoid system gland; hippocampus; male reproductive gland or organ; superior cervical ganglion; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and multiple myeloma. Orthologous to human TNFRSF17 (TNF receptor superfamily member 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 2.7), duodenum adult (RPKM 1.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfrsf17 in Genome Data Viewer
Location:
16 A1; 16 6.42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (11131131..11137938)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11313232..11320074)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:11254345-11254532 Neighboring gene G1 to S phase transition 1 Neighboring gene predicted gene, 57631 Neighboring gene microRNA 1945 Neighboring gene STARR-seq mESC enhancer starr_40101 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11322815-11323116 Neighboring gene sorting nexin 29 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11385888-11386189 Neighboring gene STARR-positive B cell enhancer ABC_E5524 Neighboring gene STARR-positive B cell enhancer ABC_E1181 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40106 Neighboring gene tyrosine-protein kinase SgK223 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Madry C, et al. Int Immunol, 1998 Nov. PMID 9846698
  2. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Xu S, et al. Mol Cell Biol, 2001 Jun. PMID 11359913, Free PMC Article
  3. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. Yang M, et al. J Immunol, 2005 Sep 1. PMID 16116167
  4. Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma. Oden F, et al. Mol Oncol, 2015 Aug. PMID 25953704, Free PMC Article
  5. [Promoter activity of B-cell maturation antigen gene in mice]. Deng SL, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2008 Aug. PMID 18687216

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA
    Title: Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.
  2. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice.
    Title: Differential Development of Systemic Lupus Erythematosus in NZM 2328 Mice Deficient in Discrete Pairs of BAFF Receptors.
  3. we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils.
    Title: Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.
  4. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR.
    Title: Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
  5. BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE.
    Title: Development of systemic lupus erythematosus in NZM 2328 mice in the absence of any single BAFF receptor.
  6. Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity.
    Title: B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.
  7. Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells.
    Title: B-lymphocyte-induced maturation protein1 up-regulates the expression of B-cell maturation antigen in mouse plasma cells.
  8. The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity.
    Title: [Promoter activity of B-cell maturation antigen gene in mice].
  9. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.
    Title: The role of the BAFF/APRIL system on T cell function.
  10. Review. APRIL interactions with BCMA likely govern memory B cell populations.
    Title: BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 17
Names
B-cell maturation protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011608.1 → NP_035738.1  tumor necrosis factor receptor superfamily member 17

    See identical proteins and their annotated locations for NP_035738.1

    Status: PROVISIONAL

    Source sequence(s)
    AF061505
    Consensus CDS
    CCDS27962.1
    UniProtKB/Swiss-Prot
    O88472
    Related
    ENSMUSP00000023140.6, ENSMUST00000023140.6
    Conserved Domains (1) summary
    cd13414
    Location:1 → 165
    TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    11131131..11137938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521990.4 → XP_006522053.1  tumor necrosis factor receptor superfamily member 17 isoform X2

    Conserved Domains (2) summary
    cd00185
    Location:1 → 18
    TNFRSF; CRD1 [structural motif]
    cl22855
    Location:1 → 112
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. XM_006521989.5 → XP_006522052.1  tumor necrosis factor receptor superfamily member 17 isoform X1

    Conserved Domains (1) summary
    cd13414
    Location:1 → 161
    TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88472.1 GenPept UniProtKB/Swiss-Prot:O88472

Gene LinkOut

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