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FAM241B family with sequence similarity 241 member B [ Homo sapiens (human) ]

Gene ID: 219738, updated on 27-Nov-2024

Summary

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Official Symbol
FAM241Bprovided by HGNC
Official Full Name
family with sequence similarity 241 member Bprovided by HGNC
Primary source
HGNC:HGNC:23519
See related
Ensembl:ENSG00000171224 AllianceGenome:HGNC:23519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf35
Summary
Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in brain (RPKM 5.1), testis (RPKM 3.6) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See FAM241B in Genome Data Viewer
Location:
10q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (69630247..69633596)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (70498296..70501645)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71390003..71393352)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MT-ND2 pseudogene 15 Neighboring gene MT-ND1 pseudogene 20 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71390546-71391431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71412271-71412952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71415742-71416520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71416521-71417298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71422303-71423252 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71445612-71446112 Neighboring gene long intergenic non-protein coding RNA 2651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71469507-71470006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71488132-71488934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71491927-71492581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71498859-71499463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71516819-71517320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71527262-71528026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71528027-71528790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71528791-71529554 Neighboring gene ribosomal protein L5 pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CRISPR knockout screen implicates three genes in lysosome function. Lenk GM, et al. Sci Rep, 2019 Jul 3. PMID 31270356, Free PMC Article
  2. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, et al. Nat Genet, 2014 Mar. PMID 24509480, Free PMC Article
  3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  5. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM241B
Names
uncharacterized protein C10orf35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145306.3 → NP_660349.1  protein FAM241B

    See identical proteins and their annotated locations for NP_660349.1

    Status: VALIDATED

    Source sequence(s)
    BC013587, CK903062, DB339258, DB465414
    Consensus CDS
    CCDS7295.1
    UniProtKB/Swiss-Prot
    Q96D05
    Related
    ENSP00000362376.4, ENST00000373279.6
    Conserved Domains (1) summary
    pfam15378
    Location:62 → 92
    DUF4605; Domain of unknown function (DUF4605)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    69630247..69633596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269606.3 → XP_005269663.1  protein FAM241B isoform X1

    UniProtKB/Swiss-Prot
    Q96D05
    Conserved Domains (1) summary
    pfam15378
    Location:105 → 134
    DUF4605; Domain of unknown function (DUF4605)

  2. XM_005269608.4 → XP_005269665.1  protein FAM241B isoform X2

    See identical proteins and their annotated locations for XP_005269665.1

    UniProtKB/Swiss-Prot
    Q96D05
    Conserved Domains (1) summary
    pfam15378
    Location:62 → 92
    DUF4605; Domain of unknown function (DUF4605)

  3. XM_011539455.3 → XP_011537757.1  protein FAM241B isoform X2

    See identical proteins and their annotated locations for XP_011537757.1

    UniProtKB/Swiss-Prot
    Q96D05
    Conserved Domains (1) summary
    pfam15378
    Location:62 → 92
    DUF4605; Domain of unknown function (DUF4605)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    70498296..70501645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365009.1 → XP_054220984.1  protein FAM241B isoform X2

    UniProtKB/Swiss-Prot
    Q96D05

  2. XM_054365008.1 → XP_054220983.1  protein FAM241B isoform X1

  3. XM_054365010.1 → XP_054220985.1  protein FAM241B isoform X2

    UniProtKB/Swiss-Prot
    Q96D05
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96D05.1 GenPept UniProtKB/Swiss-Prot:Q96D05

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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