Cmpk2 cytidine/uridine monophosphate kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmpk2provided by MGI
Official Full Name: cytidine/uridine monophosphate kinase 2provided by MGI
Primary source: MGI:MGI:99830
See related: Ensembl:ENSMUSG00000020638 AllianceGenome:MGI:99830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TDKI; Tyki; 1200004E04Rik
Summary: Predicted to enable nucleobase-containing compound kinase activity. Acts upstream of or within cellular response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including adrenal gland; genitourinary system; gut gland; liver; and nervous system. Orthologous to human CMPK2 (cytidine/uridine monophosphate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in small intestine adult (RPKM 11.2), adrenal adult (RPKM 9.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 9.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (26519121..26529836)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (26469117..26479837)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke.
Title: Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke.
Bone marrow mesenchymal stem cell-derived exosomes miR-202-5p inhibited pyroptosis to alleviate lung ischemic-reperfusion injury by targeting CMPK2.
Title: Bone marrow mesenchymal stem cell-derived exosomes miR-202-5p inhibited pyroptosis to alleviate lung ischemic-reperfusion injury by targeting CMPK2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (d)CMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables (d)CMP kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CMP kinase activity	IEA Inferred from Electronic Annotation more info
enables UMP kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables UMP/dUMP kinase activity	ISO Inferred from Sequence Orthology more info
enables dCMP kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables thymidylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thymidylate kinase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in dTDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTDP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dTTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dUDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dUDP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dUDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UMP-CMP kinase 2, mitochondrial

Names: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; nucleoside-diphosphate kinase; thymidylate kinase LPS-inducible member; thymidylate kinase homologue

NP_065582.3

EC 2.7.4.14

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020557.4 → NP_065582.3 UMP-CMP kinase 2, mitochondrial precursor

See identical proteins and their annotated locations for NP_065582.3

Status: VALIDATED

Source sequence(s)

BC057565, CA528639

Consensus CDS

CCDS49039.1

UniProtKB/Swiss-Prot

Q3U5Q7, Q3UCI7, Q5XKG5, Q62316, Q6PFG7, Q9DC34

Related

ENSMUSP00000020969.4, ENSMUST00000020969.5

Conserved Domains (2) summary

COG0125
Location:248 → 443

Tmk; Thymidylate kinase [Nucleotide transport and metabolism]

cl17190
Location:255 → 444

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...