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Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 [ Mus musculus (house mouse) ]

Gene ID: 22184, updated on 27-Nov-2024

Summary

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Official Symbol
Zrsr2provided by MGI
Official Full Name
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2provided by MGI
Primary source
MGI:MGI:103287
See related
Ensembl:ENSMUSG00000031370 AllianceGenome:MGI:103287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
URP; 35kDa; U2af1-rs2; 5031411E02Rik; A230052C13Rik
Summary
Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Predicted to be involved in spliceosomal complex assembly. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; intestine; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.6), limb E14.5 (RPKM 2.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zrsr2 in Genome Data Viewer
Location:
X F5; X 75.99 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162719268..162741662, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (163932594..163958666, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C8orf59 homolog Neighboring gene STARR-seq mESC enhancer starr_48234 Neighboring gene STARR-positive B cell enhancer ABC_E11688 Neighboring gene predicted gene, 52456 Neighboring gene adaptor-related protein complex 1, sigma 2 subunit Neighboring gene STARR-seq mESC enhancer starr_48235 Neighboring gene predicted gene, 38561 Neighboring gene carbonic anhydrase 5b, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E1986 Neighboring gene siah E3 ubiquitin protein ligase 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development. Gómez-Redondo I, et al. iScience, 2022 Feb 18. PMID 35198906, Free PMC Article
  2. Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice. Garcia-Ruiz C, et al. Leukemia, 2022 Oct. PMID 36030305, Free PMC Article
  3. Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny. Yamaoka T, et al. Genomics, 1995 May 20. PMID 7558001
  4. ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells. Madan V, et al. Haematologica, 2022 Mar 1. PMID 33691379, Free PMC Article
  5. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. Kitagawa K, et al. Genomics, 1995 Nov 20. PMID 8586425

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.
    Title: Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.
  2. ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
    Title: ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
  3. Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.
    Title: Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA 3'-splice site binding ISO
Inferred from Sequence Orthology
more info
  
enables pre-mRNA 3'-splice site binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spliceosomal complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U12-type spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2AF complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
Names
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related sequence 2
U2(RNU2) small nuclear RNA auxiliary factor 1-like 2
U2AF35-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009453.4 → NP_033479.2  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform 1

    See identical proteins and their annotated locations for NP_033479.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BX469932
    Consensus CDS
    CCDS41204.1
    UniProtKB/Swiss-Prot
    Q62377
    UniProtKB/TrEMBL
    B1B0E8
    Related
    ENSMUSP00000107908.3, ENSMUST00000112289.9
    Conserved Domains (3) summary
    smart00356
    Location:310 → 335
    ZnF_C3H1; zinc finger
    cd12540
    Location:203 → 307
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    pfam00642
    Location:171 → 195
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

  2. NM_178794.4 → NP_848909.2  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons in the 3' coding region, and has a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC065693, BX469932
    Consensus CDS
    CCDS41205.1
    UniProtKB/TrEMBL
    B1B0E9
    Related
    ENSMUSP00000088350.4, ENSMUST00000090840.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    162719268..162741662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161905.1 → XP_036017798.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

    Conserved Domains (3) summary
    smart00356
    Location:168 → 193
    ZnF_C3H1; zinc finger
    pfam00642
    Location:29 → 53
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd12540
    Location:61 → 165
    RRM_U2AFBPL; RNA recognition motif (RRM) found in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

  2. XM_036161906.1 → XP_036017799.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

    Conserved Domains (3) summary
    smart00356
    Location:168 → 193
    ZnF_C3H1; zinc finger
    pfam00642
    Location:29 → 53
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd12540
    Location:61 → 165
    RRM_U2AFBPL; RNA recognition motif (RRM) found in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

  3. XM_011247815.4 → XP_011246117.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011246117.1

    Conserved Domains (2) summary
    smart00356
    Location:102 → 127
    ZnF_C3H1; zinc finger
    cd12540
    Location:1 → 99
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

  4. XM_011247814.4 → XP_011246116.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011246116.1

    Conserved Domains (2) summary
    smart00356
    Location:102 → 127
    ZnF_C3H1; zinc finger
    cd12540
    Location:1 → 99
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

  5. XM_006528797.5 → XP_006528860.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006528860.1

    Conserved Domains (2) summary
    smart00356
    Location:102 → 127
    ZnF_C3H1; zinc finger
    cd12540
    Location:1 → 99
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62377.1 GenPept UniProtKB/Swiss-Prot:Q62377

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