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Uba1 ubiquitin-like modifier activating enzyme 1 [ Mus musculus (house mouse) ]

Gene ID: 22201, updated on 27-Nov-2024

Summary

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Official Symbol
Uba1provided by MGI
Official Full Name
ubiquitin-like modifier activating enzyme 1provided by MGI
Primary source
MGI:MGI:98890
See related
Ensembl:ENSMUSG00000001924 AllianceGenome:MGI:98890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sbx; A1S9; Ube-1; Ube1x
Summary
This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 120.8), CNS E14 (RPKM 109.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uba1 in Genome Data Viewer
Location:
X A1.3; X 16.15 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20524660..20549420)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20658302..20683179)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5720 Neighboring gene predicted gene, 23628 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene RNA binding motif protein 10 Neighboring gene STARR-positive B cell enhancer mm9_chrX:20264845-20265145 Neighboring gene cyclin dependent kinase 16 Neighboring gene ubiquitin specific peptidase 11 Neighboring gene predicted gene, 39499

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways. Chen C, et al. Immunology, 2014 Jun. PMID 24456201, Free PMC Article
  2. The functional role of UBA1 cysteine-278 in ubiquitination. Yang U, et al. Biochem Biophys Res Commun, 2012 Oct 26. PMID 23022194
  3. Crystal structure of a fragment of mouse ubiquitin-activating enzyme. Szczepanowski RH, et al. J Biol Chem, 2005 Jun 10. PMID 15774460
  4. Distinct footprints of TCR engagement with highly homologous ligands. Santori FR, et al. J Immunol, 2004 Jun 15. PMID 15187125
  5. Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton. Trausch JS, et al. Am J Physiol, 1993 Jan. PMID 8430776

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice.
    Title: Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice.
  2. Inhibition of ubiquitin-activating enzyme E1 (Ube1) increases the levels of high- molecular weight mouse Htt in relatively unaffected tissues, declining in the nuclear fraction with age.
    Title: Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues.
  3. Dysregulation of UBA1 and subsequent ubiquitination pathways led to beta-catenin accumulation in a model of spinal muscular atrophy.
    Title: Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy.
  4. These data suggest that Cys-278 can affect Ub charging through a change in the structural conformation of UBA1, not through direct interaction at the UBA1-Ub interface.
    Title: The functional role of UBA1 cysteine-278 in ubiquitination.
  5. E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage
    Title: Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.
  6. biochemical and crystallographic characterization of the two half-domains and the crystal structure of the larger, second catalytic cysteine half-domain of mouse ubiquitin-activating enzyme
    Title: Crystal structure of a fragment of mouse ubiquitin-activating enzyme.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with desmosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-like modifier-activating enzyme 1
Names
ubiquitin-activating enzyme E1, Chr X
NP_001129557.1
NP_001263245.1
NP_001263246.1
NP_033483.3
XP_030107162.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136085.3 → NP_001129557.1  ubiquitin-like modifier-activating enzyme 1

    See identical proteins and their annotated locations for NP_001129557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. All four variants encode the same protein.
    Source sequence(s)
    AL807240
    Consensus CDS
    CCDS30044.1
    UniProtKB/Swiss-Prot
    A6H6S6, P31253, Q02053, Q542H8
    UniProtKB/TrEMBL
    A0A1S6GWH5, B9EHN0
    Related
    ENSMUSP00000001989.9, ENSMUST00000001989.9
    Conserved Domains (1) summary
    TIGR01408
    Location:49 → 1055
    Ube1; ubiquitin-activating enzyme E1

  2. NM_001276316.2 → NP_001263245.1  ubiquitin-like modifier-activating enzyme 1

    See identical proteins and their annotated locations for NP_001263245.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. All four variants encode the same protein.
    Source sequence(s)
    AL807240
    Consensus CDS
    CCDS30044.1
    UniProtKB/Swiss-Prot
    A6H6S6, P31253, Q02053, Q542H8
    UniProtKB/TrEMBL
    A0A1S6GWH5, B9EHN0
    Conserved Domains (1) summary
    TIGR01408
    Location:49 → 1055
    Ube1; ubiquitin-activating enzyme E1

  3. NM_001276317.2 → NP_001263246.1  ubiquitin-like modifier-activating enzyme 1

    See identical proteins and their annotated locations for NP_001263246.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AL807240
    Consensus CDS
    CCDS30044.1
    UniProtKB/Swiss-Prot
    A6H6S6, P31253, Q02053, Q542H8
    UniProtKB/TrEMBL
    A0A1S6GWH5, B9EHN0
    Conserved Domains (1) summary
    TIGR01408
    Location:49 → 1055
    Ube1; ubiquitin-activating enzyme E1

  4. NM_009457.5 → NP_033483.3  ubiquitin-like modifier-activating enzyme 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. All four variants encode the same protein.
    Source sequence(s)
    AL807240
    UniProtKB/Swiss-Prot
    A6H6S6, P31253, Q02053, Q542H8
    UniProtKB/TrEMBL
    B9EHN0
    Related
    ENSMUSP00000086626.5, ENSMUST00000089217.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20524660..20549420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251302.1 → XP_030107162.1  ubiquitin-like modifier-activating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    A6H6S6, P31253, Q02053, Q542H8
    UniProtKB/TrEMBL
    A0A1S6GWH5, B9EHN0
    Conserved Domains (1) summary
    TIGR01408
    Location:49 → 1055
    Ube1; ubiquitin-activating enzyme E1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02053.1 GenPept UniProtKB/Swiss-Prot:Q02053

Gene LinkOut

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