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A179L bcl-2/bax homolog [ African swine fever virus ]

Gene ID: 22220423, updated on 18-Aug-2023

Summary

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Gene symbol
A179L
Gene description
bcl-2/bax homolog
Locus tag
ASFVgp037
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
African swine fever virus (strain: BA71V)
Lineage
Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Asfuvirales; Asfarviridae; Asfivirus
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Genomic context

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Sequence:
NC_001659.2 (36671..37210, complement)

NC_001659.2Genomic Context describing neighboring genes Neighboring gene IkB-like protein Neighboring gene helicase Neighboring gene structural protein p11.5 Neighboring gene pF317L

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001659.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin. Banjara S, et al. Viruses, 2019 Aug 27. PMID 31461953, Free PMC Article
  2. Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis. Banjara S, et al. J Virol, 2017 Mar 15. PMID 28053104, Free PMC Article
  3. The A179L Gene of African Swine Fever Virus Suppresses Virus-Induced Apoptosis but Enhances Necroptosis. Shi J, et al. Viruses, 2021 Dec 13. PMID 34960759, Free PMC Article
  4. Genes homologous to ubiquitin-conjugating proteins and eukaryotic transcription factor SII in African swine fever virus. Rodriguez JM, et al. Virology, 1992 Jan. PMID 1309282
  5. A gene homologous to topoisomerase II in African swine fever virus. García-Beato R, et al. Virology, 1992 Jun. PMID 1316688

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The A179L Gene of African Swine Fever Virus Suppresses Virus-Induced Apoptosis but Enhances Necroptosis.
    Title: The A179L Gene of African Swine Fever Virus Suppresses Virus-Induced Apoptosis but Enhances Necroptosis.
  2. Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin.
    Title: Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin.
  3. These findings provide a mechanistic understanding for the potent antiapoptotic activity of A179L by identifying it as the first panprodeath Bcl-2 binder.
    Title: Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
bcl-2/bax homolog
NP_042735.1
  • protein synthesis: early and late

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001659.2 Reference assembly

    Range
    36671..37210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_042735.1 bcl-2/bax homolog [African swine fever virus]

    See identical proteins and their annotated locations for NP_042735.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C8H5, P0C8H6, P42485, Q07818
    UniProtKB/TrEMBL
    A0A6G7KT82, A9JLP1, D0Q0E8, D4I5M9
    Conserved Domains (1) summary
    smart00337
    Location:43 → 134
    BCL; BCL (B-Cell lymphoma); contains BH1, BH2 regions
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2113434AP.1

Gene LinkOut

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