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Umps uridine monophosphate synthetase [ Mus musculus (house mouse) ]

Gene ID: 22247, updated on 27-Nov-2024

Summary

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Official Symbol
Umpsprovided by MGI
Official Full Name
uridine monophosphate synthetaseprovided by MGI
Primary source
MGI:MGI:1298388
See related
Ensembl:ENSMUSG00000022814 AllianceGenome:MGI:1298388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700095D23Rik
Summary
Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb bud; metanephros; pancreas; and surface ectoderm. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 16.6), liver E14.5 (RPKM 14.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Umps in Genome Data Viewer
Location:
16 B3; 16 24.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33775152..33787408, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33954782..33967038, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40715 Neighboring gene STARR-seq mESC enhancer starr_40716 Neighboring gene STARR-seq mESC enhancer starr_40719 Neighboring gene predicted gene, 34967 Neighboring gene integrin beta 5 Neighboring gene STARR-positive B cell enhancer ABC_E8630 Neighboring gene STARR-seq mESC enhancer starr_40721 Neighboring gene VISTA enhancer mm268 Neighboring gene kalirin, RhoGEF kinase Neighboring gene STARR-seq mESC enhancer starr_40723 Neighboring gene STARR-seq mESC enhancer starr_40724 Neighboring gene predicted gene, 41448 Neighboring gene STARR-seq mESC enhancer starr_40725 Neighboring gene ropporin, rhophilin associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Purification, size, and properties of the complex of orotate phosphoribosyltransferase: orotidylate decarboxylase from mouse Ehrlich ascites carcinoma. Kavipurapu PR, et al. J Biol Chem, 1976 Sep 25. PMID 965379
  2. Localization of the adenosine deaminase, transferrin, and UMP synthetase genes on Chinese hamster chromosomes 4 and 6 by in situ hybridization. Qumsiyeh MB, et al. J Hered, 1990 Mar-Apr. PMID 2338490
  3. Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase. Ohmstede CA, et al. J Biol Chem, 1986 Mar 25. PMID 2419341
  4. Control of de novo pyrimidine biosynthesis in mammalian tissues. Levels and turnover of early intermediates in mouse spleen in vivo. Hisata T, et al. Eur J Biochem, 1980 Mar. PMID 6154574
  5. Pyrimidine Metabolism: Dynamic and Versatile Pathways in Pathogens and Cellular Development. Garavito MF, et al. J Genet Genomics, 2015 May 20. PMID 26059768

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables orotate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotate phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orotate phosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables orotidine-5'-phosphate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotidine-5'-phosphate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orotidine-5'-phosphate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' UMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in lactation IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uridine 5'-monophosphate synthase
Names
UMP synthase
NP_001335016.1
NP_033497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348087.1 → NP_001335016.1  uridine 5'-monophosphate synthase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC165079, AK035997
    Conserved Domains (1) summary
    pfam00215
    Location:74 → 288
    OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family

  2. NM_009471.3 → NP_033497.1  uridine 5'-monophosphate synthase isoform 1

    See identical proteins and their annotated locations for NP_033497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC165079, AK035821, BM219105
    Consensus CDS
    CCDS28136.1
    UniProtKB/Swiss-Prot
    P13439, Q99L26
    UniProtKB/TrEMBL
    Q3TVV7, Q544K9
    Related
    ENSMUSP00000023510.7, ENSMUST00000023510.7
    Conserved Domains (2) summary
    pfam00215
    Location:252 → 466
    OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
    cl00309
    Location:9 → 204
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    33775152..33787408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13439.3 GenPept UniProtKB/Swiss-Prot:P13439

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