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Vpreb1b V-set pre-B cell surrogate light chain 1B [ Mus musculus (house mouse) ]

Gene ID: 22363, updated on 27-Nov-2024

Summary

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Official Symbol
Vpreb1bprovided by MGI
Official Full Name
V-set pre-B cell surrogate light chain 1Bprovided by MGI
Primary source
MGI:MGI:98937
See related
Ensembl:ENSMUSG00000059280 AllianceGenome:MGI:98937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD179b; VpreB1; Vpreb2; Vpreb-2
Summary
Acts upstream of or within several processes, including B cell homeostasis; B cell proliferation; and regulation of cell size. Predicted to be part of immunoglobulin complex. Is expressed in bone marrow; liver; and spleen. Orthologous to human VPREB1 (V-set pre-B cell surrogate light chain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E18 (RPKM 2.4), thymus adult (RPKM 0.3) and 4 other tissues See more
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Genomic context

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See Vpreb1b in Genome Data Viewer
Location:
16 A3; 16 11.14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17797314..17799138)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17979445..17981274)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40267 Neighboring gene solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 Neighboring gene predicted gene, 41427 Neighboring gene STARR-seq mESC enhancer starr_40270 Neighboring gene STARR-seq mESC enhancer starr_40272 Neighboring gene STARR-seq mESC enhancer starr_40274 Neighboring gene predicted gene, 49580 Neighboring gene DiGeorge syndrome critical region gene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate. Bradl H, et al. J Immunol, 2003 Sep 1. PMID 12928380
  2. Restriction fragment analysis of V preB and lambda 5 within the genus Mus. D'Hoostelaere LA, et al. Eur J Immunol, 1989 Jan. PMID 2563973
  3. Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice. Mundt C, et al. J Exp Med, 2001 Feb 19. PMID 11181696, Free PMC Article
  4. The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription. Parker MJ, et al. EMBO J, 2005 Nov 16. PMID 16281060, Free PMC Article
  5. Only VpreB1, but not VpreB2, is expressed at levels which allow normal development of B cells. Mundt C, et al. Int Immunol, 2006 Jan. PMID 16361315

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice.
    Title: Surrogate light chain expression beyond the pre-B cell stage promotes tolerance in a dose-dependent fashion.
  2. VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface.
    Title: The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.
  3. Data demonstrate that the pre-B-cell receptor is essential for monoallelic silencing of VpreB and lambda5 at the large pre-BII-cell stage.
    Title: The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.
  4. Efficient binding of a soluble murine pre-B cell receptor to stroma cells requires the non-immunoglobulin-like unique tail of lambda 5.
    Title: Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate.
  5. Mice triply deficient for VpreB2 show B cell developmental defects but functional allelic exclusion of the IgH locus.
    Title: VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within B cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of immunoglobulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
immunoglobulin omega chain
Names
Lambda 5
pre-B lymphocyte gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016983.1 → NP_058679.1  immunoglobulin omega chain precursor

    See identical proteins and their annotated locations for NP_058679.1

    Status: VALIDATED

    Source sequence(s)
    X05563
    Consensus CDS
    CCDS28015.1
    UniProtKB/Swiss-Prot
    P13373
    UniProtKB/TrEMBL
    Q0VEN0
    Related
    ENSMUSP00000074835.4, ENSMUST00000075371.5
    Conserved Domains (2) summary
    smart00410
    Location:26 → 125
    IG_like; Immunoglobulin like
    cl11960
    Location:29 → 118
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17797314..17799138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316944.3 → XP_017172433.1  immunoglobulin omega chain isoform X1

    UniProtKB/TrEMBL
    Q0VEN0
    Conserved Domains (1) summary
    cl11960
    Location:58 → 147
    Ig; Immunoglobulin domain

  2. XM_017316945.2 → XP_017172434.1  immunoglobulin omega chain isoform X1

    UniProtKB/TrEMBL
    Q0VEN0
    Conserved Domains (1) summary
    cl11960
    Location:58 → 147
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13373.1 GenPept UniProtKB/Swiss-Prot:P13373

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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