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Zc3h3 zinc finger CCCH type containing 3 [ Mus musculus (house mouse) ]

Gene ID: 223642, updated on 27-Nov-2024

Summary

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Official Symbol
Zc3h3provided by MGI
Official Full Name
zinc finger CCCH type containing 3provided by MGI
Primary source
MGI:MGI:2663721
See related
Ensembl:ENSMUSG00000075600 AllianceGenome:MGI:2663721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smicl; Zc3hdc3; Kiaa0150
Summary
Enables R-SMAD binding activity. Acts upstream of or within mRNA 3'-end processing and positive regulation of activin receptor signaling pathway. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in central nervous system and genitourinary system. Orthologous to human ZC3H3 (zinc finger CCCH-type containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 24.7), duodenum adult (RPKM 14.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zc3h3 in Genome Data Viewer
Location:
15 D3; 15 34.84 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75626279..75713772, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75754430..75842061, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene rhophilin, Rho GTPase binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10864 Neighboring gene MAF bZIP transcription factor A Neighboring gene predicted gene, 23747 Neighboring gene STARR-positive B cell enhancer ABC_E1911 Neighboring gene STARR-seq mESC enhancer starr_39021 Neighboring gene predicted gene, 34851 Neighboring gene predicted gene, 53897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. Collart C, et al. Genes Cells, 2005 Sep. PMID 16115198
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables R-SMAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of activin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 3
Names
smad-interacting CPSF-like factor
zinc finger CCCH type domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416439.1 → NP_001403368.1  zinc finger CCCH domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520

  2. NM_001416440.1 → NP_001403369.1  zinc finger CCCH domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520

  3. NM_001416441.1 → NP_001403370.1  zinc finger CCCH domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520

  4. NM_001416442.1 → NP_001403371.1  zinc finger CCCH domain-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520

  5. NM_001416443.1 → NP_001403372.1  zinc finger CCCH domain-containing protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC116393

  6. NM_001416444.1 → NP_001403373.1  zinc finger CCCH domain-containing protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC116393

  7. NM_172121.2 → NP_742119.1  zinc finger CCCH domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_742119.1

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520
    Consensus CDS
    CCDS27550.1
    UniProtKB/Swiss-Prot
    Q80X78, Q8CHP0
    UniProtKB/TrEMBL
    Q3UUL4
    Related
    ENSMUSP00000098106.3, ENSMUST00000100538.4
    Conserved Domains (2) summary
    smart00356
    Location:745 → 771
    ZnF_C3H1; zinc finger
    pfam00642
    Location:663 → 689
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RNA

  1. NR_183921.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520

  2. NR_183922.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520

  3. NR_183923.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116393, AC116520

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75626279..75713772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHP0.1 GenPept UniProtKB/Swiss-Prot:Q8CHP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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