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Cerk ceramide kinase [ Mus musculus (house mouse) ]

Gene ID: 223753, updated on 27-Nov-2024

Summary

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Official Symbol
Cerkprovided by MGI
Official Full Name
ceramide kinaseprovided by MGI
Primary source
MGI:MGI:2386052
See related
Ensembl:ENSMUSG00000035891 AllianceGenome:MGI:2386052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1646; D330016D08Rik
Summary
Enables ceramide kinase activity. Predicted to be involved in ceramide metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human CERK (ceramide kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 55.0), cerebellum adult (RPKM 36.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Cerk in Genome Data Viewer
Location:
15 E2; 15 40.52 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (86023302..86070537, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (86139101..86186259, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41375 Neighboring gene STARR-seq mESC enhancer starr_39412 Neighboring gene GRAM domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E9422 Neighboring gene predicted gene 15722 Neighboring gene STARR-positive B cell enhancer mm9_chr15:86003680-86003981 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86012285-86012732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86013160-86013361 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86033071-86033180 Neighboring gene RIKEN cDNA 2810001A02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7404 Neighboring gene predicted gene 15569 Neighboring gene TBC1 domain family, member 22a Neighboring gene predicted gene, 22818

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality. Tanaka A, et al. J Pharmacol Sci, 2022 Sep. PMID 35926944
  2. The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells. Mitsutake S, et al. Biochem Biophys Res Commun, 2007 Nov 23. PMID 17888878
  3. Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin. Boath A, et al. J Biol Chem, 2008 Mar 28. PMID 18086664
  4. Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice. Graf C, et al. J Immunol, 2008 Mar 1. PMID 18292572
  5. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Niwa S, et al. Microvasc Res, 2009 May. PMID 19323974

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.
    Title: Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.
  2. Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality.
    Title: Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality.
  3. Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice.
    Title: Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice.
  4. MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.
    Title: MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.
  5. the data presented in this work suggest that exogenous C1P may balance adipogenesis, and that targeting CerK may be a novel way for potential applications in the treatment of obesity or other inflammation-associated diseases
    Title: Regulation of adipogenesis by ceramide 1-phosphate.
  6. results suggest that intracellular ceramide kinase is required for the migration of bone marrow-derived mesenchymal stem cells, and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation
    Title: Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells.
  7. The depletion of CerK enhances the pathology of colitis and lethal responses in DSS-treated mice.
    Title: Knockout of Ceramide Kinase Aggravates Pathological and Lethal Responses in Mice with Experimental Colitis.
  8. these studies demonstrate a novel requirement for the CERK-derived C1P in the proper healing response of wounds.
    Title: Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts.
  9. there are significant differences in eicosanoid levels in ex vivo CERK(-/-) cells compared with wild-type counterparts, but the effect of the genetic ablation of CERK on eicosanoid synthesis and the serum levels of C1P was not apparent in vivo
    Title: Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase.
  10. role of ceramide kinase in obesity and insulin resistance
    Title: Ceramide kinase deficiency improves diet-induced obesity and insulin resistance.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ceramide kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ceramide kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ceramide kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ceramide kinase
Names
acylsphingosine kinase
mCERK
NP_663450.3
XP_011243890.1
XP_030104368.1
XP_030104369.1
XP_036015253.1
XP_036015254.1
XP_036015255.1
XP_036015256.1
XP_036015257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145475.4 → NP_663450.3  ceramide kinase

    See identical proteins and their annotated locations for NP_663450.3

    Status: VALIDATED

    Source sequence(s)
    AC116764, AK042077, AK052269, BU756835
    Consensus CDS
    CCDS27728.1
    UniProtKB/Swiss-Prot
    Q52KP2, Q8K4Q7
    Related
    ENSMUSP00000038203.10, ENSMUST00000044332.16
    Conserved Domains (1) summary
    PLN02204
    Location:84 → 528
    PLN02204; diacylglycerol kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    86023302..86070537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159362.1 → XP_036015255.1  ceramide kinase isoform X4

    UniProtKB/TrEMBL
    Q6ZPK5
    Related
    ENSMUST00000150767.8
    Conserved Domains (1) summary
    cl01255
    Location:7 → 451
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. XM_011245588.4 → XP_011243890.1  ceramide kinase isoform X3

    Conserved Domains (1) summary
    PLN02204
    Location:84 → 477
    PLN02204; diacylglycerol kinase

  3. XM_030248509.2 → XP_030104369.1  ceramide kinase isoform X8

    Conserved Domains (1) summary
    cl01255
    Location:20 → 279
    DAGK_cat; Diacylglycerol kinase catalytic domain

  4. XM_030248508.2 → XP_030104368.1  ceramide kinase isoform X7

    UniProtKB/TrEMBL
    Q6ZPK5
    Conserved Domains (1) summary
    PLN02204
    Location:20 → 330
    PLN02204; diacylglycerol kinase

  5. XM_036159361.1 → XP_036015254.1  ceramide kinase isoform X2

    Conserved Domains (1) summary
    cl01255
    Location:84 → 415
    DAGK_cat; Diacylglycerol kinase catalytic domain

  6. XM_036159363.1 → XP_036015256.1  ceramide kinase isoform X5

    Conserved Domains (1) summary
    cl01255
    Location:20 → 268
    DAGK_cat; Diacylglycerol kinase catalytic domain

  7. XM_036159360.1 → XP_036015253.1  ceramide kinase isoform X1

    Conserved Domains (1) summary
    cl01255
    Location:84 → 466
    DAGK_cat; Diacylglycerol kinase catalytic domain

  8. XM_036159364.1 → XP_036015257.1  ceramide kinase isoform X6

    Conserved Domains (1) summary
    cl01255
    Location:84 → 331
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4Q7.2 GenPept UniProtKB/Swiss-Prot:Q8K4Q7

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