Brd1 bromodomain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brd1provided by MGI
Official Full Name: bromodomain containing 1provided by MGI
Primary source: MGI:MGI:1924161
See related: Ensembl:ENSMUSG00000022387 AllianceGenome:MGI:1924161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4191; 1110059H06Rik
Summary: Enables histone reader activity. Involved in positive regulation of erythrocyte differentiation. Part of histone H3-K14 acetyltransferase complex. Is expressed in brain; genitourinary system; and olfactory epithelium. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human BRD1 (bromodomain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.6), CNS E14 (RPKM 5.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.17 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (88571237..88618508, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (88687034..88734228, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping.
Title: Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping.
Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.
Title: Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.
Brd1(+/-) mice exhibit relational encoding deficits, compromised working and long term memory, as well as impaired executive cognitive functioning with cognitive behaviors relying on medial prefrontal cortex being particularly affected. Akin to patients with schizophrenia, the cognitive deficits displayed by Brd1(+/)(-) mice are not global, but selective.
Title: Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.
results demonstrate widespread gene expression alterations in the brains of Brd1 +/- mice.
Title: The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice.
BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.
Title: The BRPF2/BRD1-MOZ complex is involved in retinoic acid-induced differentiation of embryonic stem cells.
Brd1-mediated Hbo1 activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers.
Title: Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
The Hbo1-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator genes.
Title: The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Ertd55e (e-PCR), detects polymorphism
- UniSTS:167169

RH136139 (e-PCR)
- UniSTS:210134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to immobilization stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of MOZ/MORF histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of histone H3-K14 acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone H3-K14 acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain-containing protein 1

Names: bromodomain and PHD finger-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033274.3 → NP_001028446.2 bromodomain-containing protein 1

Status: VALIDATED

Source sequence(s)

AK149714, AK220233, BB610711, BC037388, BC152356

Consensus CDS

CCDS27730.2

UniProtKB/TrEMBL

A7MCW6, E9PZ26, Q3UE68, Q571F6

Related

ENSMUSP00000105007.2, ENSMUST00000109381.9

Conserved Domains (5) summary

cd05839
Location:1058 → 1173

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

cd15677
Location:214 → 267

PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

88571237..88618508 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248510.2 → XP_030104370.1 bromodomain-containing protein 1 isoform X4

Conserved Domains (5) summary

cd05839
Location:897 → 1012

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

COG5141
Location:139 → 572

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like

cl02556
Location:566 → 633

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_006520834.4 → XP_006520897.1 bromodomain-containing protein 1 isoform X2

Conserved Domains (5) summary

cd05839
Location:1028 → 1143

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

COG5141
Location:139 → 572

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like

cl02556
Location:566 → 633

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_006520836.4 → XP_006520899.1 bromodomain-containing protein 1 isoform X5

Conserved Domains (5) summary

cd05839
Location:892 → 1007

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:139 → 572

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like
XM_006520835.4 → XP_006520898.1 bromodomain-containing protein 1 isoform X3

See identical proteins and their annotated locations for XP_006520898.1

UniProtKB/Swiss-Prot

E9PZ26, G5E8P1, Q571F6, Q8BU83

Related

ENSMUSP00000105006.2, ENSMUST00000109380.8

Conserved Domains (5) summary

cd05839
Location:927 → 1042

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:139 → 572

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like
XM_036159368.1 → XP_036015261.1 bromodomain-containing protein 1 isoform X1

Conserved Domains (5) summary

cd05839
Location:1047 → 1162

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:566 → 663

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:139 → 572

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15702
Location:271 → 388

ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

pfam10513
Location:47 → 196

EPL1; Enhancer of polycomb-like