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Slc7a4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 [ Mus musculus (house mouse) ]

Gene ID: 224022, updated on 27-Nov-2024

Summary

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Official Symbol
Slc7a4provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4provided by MGI
Primary source
MGI:MGI:2146512
See related
Ensembl:ENSMUSG00000022756 AllianceGenome:MGI:2146512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; nose; and testis. Orthologous to human SLC7A4 (solute carrier family 7 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 44.4), ovary adult (RPKM 14.2) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Slc7a4 in Genome Data Viewer
Location:
16 A3; 16 10.89 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17389882..17394619, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17572018..17576890, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 74B Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 6 Neighboring gene STARR-seq mESC enhancer starr_40258 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17619324-17619507 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene STARR-seq mESC enhancer starr_40259 Neighboring gene coiled-coil domain containing 74A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Racedo SE, et al. Am J Hum Genet, 2015 Feb 5. PMID 25658046, Free PMC Article
  2. Risk of meningomyelocele mediated by the common 22q11.2 deletion. Vong KI, et al. Science, 2024 May 3. PMID 38696583
  3. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. O'Shaughnessy PJ, et al. Endocrinology, 2007 Jun. PMID 17332066
  4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC27672

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxylic acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carboxylic acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cationic amino acid transporter 4
Names
CAT-4
CAT4
solute carrier family 7 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359891.2 → NP_001346820.1  cationic amino acid transporter 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC115733
    Consensus CDS
    CCDS28008.1
    UniProtKB/Swiss-Prot
    Q8BLQ7
    UniProtKB/TrEMBL
    Q8BML4
    Conserved Domains (1) summary
    TIGR00906
    Location:14 → 592
    2A0303; cationic amino acid transport permease

  2. NM_001359892.2 → NP_001346821.1  cationic amino acid transporter 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115733
    Conserved Domains (1) summary
    cl26159
    Location:79 → 657
    AA_permease_2; Amino acid permease

  3. NM_001359893.2 → NP_001346822.1  cationic amino acid transporter 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC115733
    Consensus CDS
    CCDS28008.1
    UniProtKB/Swiss-Prot
    Q8BLQ7
    UniProtKB/TrEMBL
    Q8BML4
    Conserved Domains (1) summary
    TIGR00906
    Location:14 → 592
    2A0303; cationic amino acid transport permease

  4. NM_001416939.1 → NP_001403868.1  cationic amino acid transporter 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115733
    UniProtKB/Swiss-Prot
    Q8BLQ7

  5. NM_001416940.1 → NP_001403869.1  cationic amino acid transporter 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115733
    UniProtKB/Swiss-Prot
    Q8BLQ7

  6. NM_001416941.1 → NP_001403870.1  cationic amino acid transporter 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115733
    UniProtKB/Swiss-Prot
    Q8BLQ7

  7. NM_001416942.1 → NP_001403871.1  cationic amino acid transporter 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115733
    Related
    ENSMUSP00000156166.2, ENSMUST00000232226.2

  8. NM_001416943.1 → NP_001403872.1  cationic amino acid transporter 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115733

  9. NM_001416944.1 → NP_001403873.1  cationic amino acid transporter 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115733
    UniProtKB/TrEMBL
    A0A338P754

  10. NM_001416945.1 → NP_001403874.1  cationic amino acid transporter 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115733
    UniProtKB/TrEMBL
    A0A338P754
    Related
    ENSMUSP00000156098.2, ENSMUST00000232385.2

  11. NM_001416946.1 → NP_001403875.1  cationic amino acid transporter 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115733
    UniProtKB/TrEMBL
    A0A338P754
    Related
    ENSMUSP00000156027.2, ENSMUST00000231615.2

  12. NM_001416947.1 → NP_001403876.1  cationic amino acid transporter 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115733

  13. NM_144852.3 → NP_659101.2  cationic amino acid transporter 4 isoform 2

    See identical proteins and their annotated locations for NP_659101.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK043772
    Consensus CDS
    CCDS28008.1
    UniProtKB/Swiss-Prot
    Q8BLQ7
    UniProtKB/TrEMBL
    Q8BML4
    Related
    ENSMUSP00000127280.2, ENSMUST00000172164.10
    Conserved Domains (1) summary
    TIGR00906
    Location:14 → 592
    2A0303; cationic amino acid transport permease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17389882..17394619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_875780.4 RNA Sequence

  2. XR_875779.4 RNA Sequence

  3. XR_384551.5 RNA Sequence

  4. XR_384549.5 RNA Sequence

    Related
    ENSMUST00000232429.2

  5. XR_384548.4 RNA Sequence

  6. XR_004939182.1 RNA Sequence

  7. XR_875781.3 RNA Sequence

  8. XR_384553.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLQ7.1 GenPept UniProtKB/Swiss-Prot:Q8BLQ7

Gene LinkOut

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