Atp13a3 ATPase type 13A3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp13a3provided by MGI
Official Full Name: ATPase type 13A3provided by MGI
Primary source: MGI:MGI:2685387
See related: Ensembl:ENSMUSG00000022533 AllianceGenome:MGI:2685387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm541; Gm542; Gm1745
Summary: Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type transmembrane transporter activity; and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be located in early endosome membrane and recycling endosome membrane. Predicted to be active in late endosome membrane. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 11.5), placenta adult (RPKM 10.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B2; 16 21.26 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (30131241..30207674, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (30312423..30388871, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.
Title: ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C79226 (e-PCR)
- UniSTS:209202

AU022875 (e-PCR)
- UniSTS:209203

AA965213 (e-PCR)
- UniSTS:261305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type putrescine transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type ion transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables polyamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polyamine-transporting ATPase 13A3

Names: probable cation-transporting ATPase 13A3; putrescine transporting ATPase; type V P-type ATPase

NP_001121566.1

EC 7.6.2.16

NP_001121568.1

EC 7.6.2.16

XP_011244181.1

EC 7.6.2.16

XP_036015785.1

EC 7.6.2.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128094.1 → NP_001121566.1 polyamine-transporting ATPase 13A3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC154608, BK005558

Consensus CDS

CCDS49820.1

UniProtKB/Swiss-Prot

Q5XF89

Related

ENSMUSP00000051645.7, ENSMUST00000061350.13

Conserved Domains (6) summary

TIGR01657
Location:14 → 1142

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:232 → 479

E1-E2_ATPase; E1-E2 ATPase

pfam00690
Location:174 → 222

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12409
Location:13 → 141

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:618 → 658

Cation_ATPase; Cation transport ATPase (P-type)

cl21460
Location:817 → 894

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001128096.1 → NP_001121568.1 polyamine-transporting ATPase 13A3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC154608

Consensus CDS

CCDS49821.1

UniProtKB/Swiss-Prot

Q5XF89

Related

ENSMUSP00000128224.2, ENSMUST00000100013.9

Conserved Domains (1) summary

TIGR01657
Location:14 → 1142

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

30131241..30207674 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245879.4 → XP_011244181.1 polyamine-transporting ATPase 13A3 isoform X2

Conserved Domains (1) summary

TIGR01657
Location:14 → 1115

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
XM_036159892.1 → XP_036015785.1 polyamine-transporting ATPase 13A3 isoform X1

Conserved Domains (1) summary

TIGR01657
Location:14 → 1142

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)