Adgrf5 adhesion G protein-coupled receptor F5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrf5provided by MGI
Official Full Name: adhesion G protein-coupled receptor F5provided by MGI
Primary source: MGI:MGI:2182928
See related: Ensembl:ENSMUSG00000056492 AllianceGenome:MGI:2182928
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr116; mKIAA0758; 9330185D23; 8430401C09Rik
Summary: Predicted to enable G protein-coupled receptor activity. Involved in surfactant homeostasis. Acts upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ADGRF5 (adhesion G protein-coupled receptor F5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 73.9), subcutaneous fat pad adult (RPKM 17.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 19.73 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (43671225..43770448)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (43360329..43459557)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development.
Title: The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development.
GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc[-]/GSH/GPX4.
Title: GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc(-)/GSH/GPX4.
The transcription factor Foxi1 promotes expression of V-ATPase and Gpr116 in M-1 cells.
Title: The transcription factor Foxi1 promotes expression of V-ATPase and Gpr116 in M-1 cells.
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Title: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
Title: Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
these results reveal a previously unobserved vascular morphogenetic defect in Adgrf5 knockout mice, implicating a role for ADGRF5 in the initiation of subretinal vascularization.
Title: Adgrf5 contributes to patterning of the endothelial deep layer in retina.
Targeted disruption of ADGRF5 results in the development of airway inflammation.
Title: Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells.
loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.
Title: Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).
Results indicate the function of adhesion receptor Gpr116 in lung and in the central nervous system vasculature.
Title: Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium.
These results suggest that Ig-Hepta plays an important role in regulating macrophage immune responses, and its deficiency leads to local inflammation in the lung
Title: Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4) 1 citation
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136181 (e-PCR)
- UniSTS:210176

Gpr116 (e-PCR), detects polymorphism
- UniSTS:547986

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within energy reserve metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glomerular filtration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal arch artery morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor F5

Names: G protein coupled receptor Gpr116; G protein-coupled receptor 116; probable G-protein coupled receptor 116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081178.2 → NP_001074647.1 adhesion G protein-coupled receptor F5 isoform 1 precursor

See identical proteins and their annotated locations for NP_001074647.1

Status: VALIDATED

Source sequence(s)

AC169504, CT010585, CT025700

Consensus CDS

CCDS37622.1

UniProtKB/Swiss-Prot

G5E8Q8

UniProtKB/TrEMBL

A0A286YDT5

Related

ENSMUSP00000109229.2, ENSMUST00000113599.2

Conserved Domains (5) summary

smart00409
Location:283 → 357

IG; Immunoglobulin

pfam01825
Location:951 → 998

GPS; GPCR proteolysis site, GPS, motif

pfam13927
Location:471 → 544

Ig_3; Immunoglobulin domain

cd14964
Location:1013 → 1038

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1012 → 1285

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001357332.1 → NP_001344261.1 adhesion G protein-coupled receptor F5 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC169504, AW457181, CT010585, CT025700

UniProtKB/TrEMBL

A0A286YDT5

Conserved Domains (5) summary

smart00410
Location:301 → 375

IG_like; Immunoglobulin like

cd14964
Location:1032 → 1056

7tm_GPCRs; TM helix 1 [structural motif]

pfam00047
Location:495 → 568

ig; Immunoglobulin domain

pfam01825
Location:969 → 1016

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:1030 → 1303

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001404529.1 → NP_001391458.1 adhesion G protein-coupled receptor F5 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC169504, CT010585, CT025700
NM_001404530.1 → NP_001391459.1 adhesion G protein-coupled receptor F5 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC169504, CT010585, CT025700
NM_001404536.1 → NP_001391465.1 adhesion G protein-coupled receptor F5 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC169504, CT010585, CT025700
NM_001404541.1 → NP_001391470.1 adhesion G protein-coupled receptor F5 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC169504, CT010585, CT025700
NM_001404546.1 → NP_001391475.1 adhesion G protein-coupled receptor F5 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC169504, CT010585, CT025700
NM_001404548.1 → NP_001391477.1 adhesion G protein-coupled receptor F5 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC169504, CT010585, CT025700

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

43671225..43770448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524128.5 → XP_006524191.1 adhesion G protein-coupled receptor F5 isoform X3

See identical proteins and their annotated locations for XP_006524191.1

UniProtKB/TrEMBL

A0A286YDT5

Related

ENSMUSP00000153373.2, ENSMUST00000225962.2

Conserved Domains (5) summary

smart00409
Location:283 → 357

IG; Immunoglobulin

cd14964
Location:1053 → 1078

7tm_GPCRs; TM helix 1 [structural motif]

pfam00047
Location:517 → 590

ig; Immunoglobulin domain

pfam01825
Location:991 → 1038

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:1052 → 1325

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036160548.1 → XP_036016441.1 adhesion G protein-coupled receptor F5 isoform X7

UniProtKB/Swiss-Prot

G5E8Q8

UniProtKB/TrEMBL

A0A286YDT5

Related

ENSMUSP00000153049.2, ENSMUST00000226087.2

Conserved Domains (5) summary

smart00409
Location:283 → 357

IG; Immunoglobulin

pfam01825
Location:951 → 998

GPS; GPCR proteolysis site, GPS, motif

pfam13927
Location:471 → 544

Ig_3; Immunoglobulin domain

cd14964
Location:1013 → 1038

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1012 → 1285

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036160547.1 → XP_036016440.1 adhesion G protein-coupled receptor F5 isoform X6

Conserved Domains (5) summary

smart00409
Location:301 → 375

IG; Immunoglobulin

pfam00047
Location:491 → 568

ig; Immunoglobulin domain

pfam01825
Location:969 → 1016

GPS; GPCR proteolysis site, GPS, motif

cd14964
Location:1031 → 1056

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1030 → 1303

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036160550.1 → XP_036016443.1 adhesion G protein-coupled receptor F5 isoform X8

Conserved Domains (5) summary

smart00409
Location:283 → 357

IG; Immunoglobulin

pfam00047
Location:473 → 550

ig; Immunoglobulin domain

pfam01825
Location:951 → 998

GPS; GPCR proteolysis site, GPS, motif

cd14964
Location:1013 → 1038

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1012 → 1285

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036160549.1 → XP_036016442.1 adhesion G protein-coupled receptor F5 isoform X8

Conserved Domains (5) summary

smart00409
Location:283 → 357

IG; Immunoglobulin

pfam00047
Location:473 → 550

ig; Immunoglobulin domain

pfam01825
Location:951 → 998

GPS; GPCR proteolysis site, GPS, motif

cd14964
Location:1013 → 1038

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:1012 → 1285

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily