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Fbxo11 F-box protein 11 [ Mus musculus (house mouse) ]

Gene ID: 225055, updated on 27-Nov-2024

Summary

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Official Symbol
Fbxo11provided by MGI
Official Full Name
F-box protein 11provided by MGI
Primary source
MGI:MGI:2147134
See related
Ensembl:ENSMUSG00000005371 AllianceGenome:MGI:2147134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jf
Summary
Enables ubiquitin-protein transferase activity. Involved in sensory perception of sound. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and respiratory system. Used to study otitis media. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 23.5), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo11 in Genome Data Viewer
Location:
17 E4; 17 57.87 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88298287..88373473, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87990859..88066045, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43521 Neighboring gene predicted gene, 41649 Neighboring gene STARR-seq mESC enhancer starr_43523 Neighboring gene STARR-seq mESC enhancer starr_43524 Neighboring gene STARR-seq mESC enhancer starr_43525 Neighboring gene STARR-seq mESC enhancer starr_43526 Neighboring gene STARR-seq mESC enhancer starr_43527 Neighboring gene ribosomal protein L36, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_43528 Neighboring gene STARR-seq mESC enhancer starr_43529 Neighboring gene STARR-seq mESC enhancer starr_43530 Neighboring gene STARR-positive B cell enhancer ABC_E9446 Neighboring gene STARR-seq mESC enhancer starr_43533 Neighboring gene STARR-positive B cell enhancer ABC_E7566 Neighboring gene mutS homolog 6 Neighboring gene STARR-positive B cell enhancer ABC_E8701 Neighboring gene STARR-positive B cell enhancer ABC_E4235 Neighboring gene STARR-positive B cell enhancer ABC_E5642 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88465439-88465740 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:88465818-88465927 Neighboring gene STARR-seq mESC enhancer starr_43538 Neighboring gene STARR-positive B cell enhancer ABC_E1513 Neighboring gene STARR-positive B cell enhancer ABC_E5643 Neighboring gene STARR-seq mESC enhancer starr_43539 Neighboring gene predicted gene 4832 Neighboring gene predicted gene, 31499

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FBXO11 regulates bone development. Huang H, et al. Bone, 2023 May. PMID 36863499, Free PMC Article
  2. The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects. Kubinyecz O, et al. Front Genet, 2020. PMID 32508883, Free PMC Article
  3. Mutation in Fbxo11 Leads to Altered Immune Cell Content in Jeff Mouse Model of Otitis Media. Vikhe PP, et al. Front Genet, 2020. PMID 32117459, Free PMC Article
  4. FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease. Schneider C, et al. Blood, 2016 Aug 4. PMID 27166359, Free PMC Article
  5. Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity. Bagger SO, et al. Mol Cancer, 2018 Dec 10. PMID 30526604, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
    Title: FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
  2. FBXO11 regulates bone development.
    Title: FBXO11 regulates bone development.
  3. Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.
    Title: Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.
  4. a bulla cavitation defect initiates the pathogenesis of otitis media in the established mouse model Jeff (Fbxo11(Jf/+) ).
    Title: Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.
  5. Through a loss-of-function screen authors found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis.
    Title: Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.
  6. FBXO11 inactivation was associated with the development of lymphoproliferative disorders in mice.
    Title: FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease.
  7. FBXO11 regulates the TGF-beta pathway in the embryonic lung via cross-talk with p53.
    Title: Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.
  8. Relationship between dilation of endoplasmic reticulum and decreased levels of the FBXO11 gene in vitiligo melanocytes.
    Title: VIT1/FBXO11 knockdown induces morphological alterations and apoptosis in B10BR mouse melanocytes.
  9. FBXO11 is one of the first molecules to be identified, contributing to the genetic aetiology of otitis media
    Title: A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC156416

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081034.3 → NP_001074503.1  F-box only protein 11 isoform 1

    See identical proteins and their annotated locations for NP_001074503.1

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673, AI853268, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
    Consensus CDS
    CCDS37717.1
    UniProtKB/Swiss-Prot
    A1A595, E9QP06, Q08EB9, Q08EC0, Q7TPD1, Q80UP0
    Related
    ENSMUSP00000005504.9, ENSMUST00000005504.15
    Conserved Domains (3) summary
    pfam12937
    Location:160 → 203
    F-box-like; F-box-like
    pfam13229
    Location:667 → 812
    Beta_helix; Right handed beta helix region
    cl19744
    Location:853 → 894
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  2. NM_001348248.1 → NP_001335177.1  F-box only protein 11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC087233, AC154673, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
    UniProtKB/Swiss-Prot
    Q7TPD1
    Conserved Domains (3) summary
    pfam12937
    Location:73 → 116
    F-box-like
    pfam13229
    Location:580 → 739
    Beta_helix; Right handed beta helix region
    cl19744
    Location:766 → 807
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  3. NM_001379303.1 → NP_001366232.1  F-box only protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673
    Conserved Domains (3) summary
    pfam12937
    Location:159 → 202
    F-box-like
    pfam13229
    Location:666 → 825
    Beta_helix; Right handed beta helix region
    cl19744
    Location:852 → 893
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  4. NM_001379304.1 → NP_001366233.1  F-box only protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673
    Conserved Domains (3) summary
    pfam12937
    Location:73 → 116
    F-box-like
    pfam13229
    Location:580 → 739
    Beta_helix; Right handed beta helix region
    cl19744
    Location:766 → 807
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  5. NM_001379305.1 → NP_001366234.1  F-box only protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673
    Related
    ENSMUSP00000121206.3, ENSMUST00000130379.9
    Conserved Domains (3) summary
    pfam12937
    Location:72 → 115
    F-box-like
    pfam13229
    Location:579 → 738
    Beta_helix; Right handed beta helix region
    cl19744
    Location:765 → 806
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  6. NM_001414440.1 → NP_001401369.1  F-box only protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    88298287..88373473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPD1.3 GenPept UniProtKB/Swiss-Prot:Q7TPD1

Gene LinkOut

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