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Eml3 echinoderm microtubule associated protein like 3 [ Mus musculus (house mouse) ]

Gene ID: 225898, updated on 4-Jan-2025

Summary

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Official Symbol
Eml3provided by MGI
Official Full Name
echinoderm microtubule associated protein like 3provided by MGI
Primary source
MGI:MGI:2387612
See related
Ensembl:ENSMUSG00000071647 AllianceGenome:MGI:2387612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emap-3
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; mitotic metaphase chromosome alignment; and regulation of mitotic spindle assembly. Predicted to be located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. Predicted to colocalize with mitotic spindle. Orthologous to human EML3 (EMAP like 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in adrenal adult (RPKM 29.9), spleen adult (RPKM 28.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eml3 in Genome Data Viewer
Location:
19 A; 19 6.04 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8904584..8918946)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8929663..8941582)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4265 Neighboring gene alpha glucosidase 2 alpha neutral subunit Neighboring gene STARR-seq mESC enhancer starr_45501 Neighboring gene predicted gene, 36629 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene STARR-positive B cell enhancer ABC_E5684 Neighboring gene metastasis-associated gene family, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E11018 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896
  2. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC37888, MGC38588

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in spindle microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
echinoderm microtubule-associated protein-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374671.1 → NP_001361600.1  echinoderm microtubule-associated protein-like 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129217, BC034112
    UniProtKB/TrEMBL
    A0A286YDN1
    Related
    ENSMUSP00000153500.2, ENSMUST00000224272.2
    Conserved Domains (3) summary
    sd00039
    Location:517 → 555
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:215 → 284
    HELP; HELP motif
    cl29593
    Location:551 → 868
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_144872.1 → NP_659121.1  echinoderm microtubule-associated protein-like 3 isoform 1

    See identical proteins and their annotated locations for NP_659121.1

    Status: VALIDATED

    Source sequence(s)
    BC022146
    Consensus CDS
    CCDS29560.1
    UniProtKB/Swiss-Prot
    Q8R1S1, Q8VC03
    Related
    ENSMUSP00000093960.5, ENSMUST00000096241.6
    Conserved Domains (4) summary
    sd00039
    Location:518 → 556
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:216 → 285
    HELP; HELP motif
    cd21949
    Location:6 → 34
    TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3
    cl29593
    Location:552 → 869
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8904584..8918946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161541.1 → XP_036017434.1  echinoderm microtubule-associated protein-like 3 isoform X2

    Conserved Domains (3) summary
    sd00039
    Location:489 → 527
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:187 → 256
    HELP; HELP motif
    cl29593
    Location:523 → 840
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_036161540.1 → XP_036017433.1  echinoderm microtubule-associated protein-like 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8R1S1, Q8VC03
    Conserved Domains (4) summary
    sd00039
    Location:518 → 556
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:216 → 285
    HELP; HELP motif
    cd21949
    Location:6 → 34
    TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3
    cl29593
    Location:552 → 869
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004940136.1 RNA Sequence

  2. XR_004940137.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC03.1 GenPept UniProtKB/Swiss-Prot:Q8VC03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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