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Lzts2 leucine zipper, putative tumor suppressor 2 [ Mus musculus (house mouse) ]

Gene ID: 226154, updated on 27-Nov-2024

Summary

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Official Symbol
Lzts2provided by MGI
Official Full Name
leucine zipper, putative tumor suppressor 2provided by MGI
Primary source
MGI:MGI:2385095
See related
Ensembl:ENSMUSG00000035342 AllianceGenome:MGI:2385095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAPSER1; mKIAA1813
Summary
Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of fibroblast proliferation; and tube morphogenesis. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch mandibular component; adrenal gland; forelimb bud; future brain; and genitourinary system. Used to study urinary system disease. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 94.4), ovary adult (RPKM 63.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Lzts2 in Genome Data Viewer
Location:
19 C3; 19 38.2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45003615..45015554)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45015176..45027115)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G Neighboring gene STARR-positive B cell enhancer ABC_E9998 Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene PDZ domain containing 7 Neighboring gene sideroflexin 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45131818-45132020 Neighboring gene STARR-positive B cell enhancer ABC_E9175 Neighboring gene predicted gene, 35782 Neighboring gene Kazal-type serine peptidase inhibitor domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis. Yu EJ, et al. PLoS One, 2017. PMID 28323888, Free PMC Article
  2. Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development. Johnson DT, et al. J Biol Chem, 2013 Feb 8. PMID 23275340, Free PMC Article
  3. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. Peng Y, et al. J Biol Chem, 2011 Nov 18. PMID 21949185, Free PMC Article
  4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data demonstrate the significance of simultaneous Pten and Lzts2 deletion in oncogenic transformation in prostate cells and implicates a new mechanism for the dysregulation of Wnt/beta-catenin signaling in prostate tumorigenesis.
    Title: LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis.
  2. deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development.
    Title: Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.
  3. a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of beta-catenin-mediated nephrogenesis.
    Title: The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7094

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule severing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear export IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within primary ureteric bud growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle midzone assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ureter morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine zipper putative tumor suppressor 2
Names
protein LAPSER1
putative tumor suppressor LAPSER1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130525.1 → NP_001123997.1  leucine zipper putative tumor suppressor 2

    See identical proteins and their annotated locations for NP_001123997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AA208269, AK129446, BX511791, CK021048
    Consensus CDS
    CCDS29855.1
    UniProtKB/Swiss-Prot
    E9QKK6, Q569X6, Q91YU6
    Related
    ENSMUSP00000137571.2, ENSMUST00000179108.9
    Conserved Domains (2) summary
    pfam06818
    Location:441 → 637
    Fez1
    pfam13851
    Location:404 → 476
    GAS; Growth-arrest specific micro-tubule binding

  2. NM_001130526.1 → NP_001123998.1  leucine zipper putative tumor suppressor 2

    See identical proteins and their annotated locations for NP_001123998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AA208269, AK129446, BY726859, CK021048
    Consensus CDS
    CCDS29855.1
    UniProtKB/Swiss-Prot
    E9QKK6, Q569X6, Q91YU6
    Related
    ENSMUSP00000136405.2, ENSMUST00000178087.3
    Conserved Domains (2) summary
    pfam06818
    Location:441 → 637
    Fez1
    pfam13851
    Location:404 → 476
    GAS; Growth-arrest specific micro-tubule binding

  3. NM_145503.2 → NP_663478.2  leucine zipper putative tumor suppressor 2

    See identical proteins and their annotated locations for NP_663478.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AA208269, AK129446, BY202542, CK021048
    Consensus CDS
    CCDS29855.1
    UniProtKB/Swiss-Prot
    E9QKK6, Q569X6, Q91YU6
    Related
    ENSMUSP00000045478.7, ENSMUST00000039016.14
    Conserved Domains (2) summary
    pfam06818
    Location:441 → 637
    Fez1
    pfam13851
    Location:404 → 476
    GAS; Growth-arrest specific micro-tubule binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45003615..45015554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527004.4 → XP_006527067.1  leucine zipper putative tumor suppressor 2 isoform X1

    See identical proteins and their annotated locations for XP_006527067.1

    UniProtKB/Swiss-Prot
    E9QKK6, Q569X6, Q91YU6
    Conserved Domains (2) summary
    pfam06818
    Location:441 → 637
    Fez1
    pfam13851
    Location:404 → 476
    GAS; Growth-arrest specific micro-tubule binding

  2. XM_030250898.2 → XP_030106758.1  leucine zipper putative tumor suppressor 2 isoform X1

    UniProtKB/Swiss-Prot
    E9QKK6, Q569X6, Q91YU6
    Conserved Domains (2) summary
    pfam06818
    Location:441 → 637
    Fez1
    pfam13851
    Location:404 → 476
    GAS; Growth-arrest specific micro-tubule binding

  3. XM_030250899.2 → XP_030106759.1  leucine zipper putative tumor suppressor 2 isoform X1

    UniProtKB/Swiss-Prot
    E9QKK6, Q569X6, Q91YU6
    Conserved Domains (2) summary
    pfam06818
    Location:441 → 637
    Fez1
    pfam13851
    Location:404 → 476
    GAS; Growth-arrest specific micro-tubule binding

  4. XM_006527005.5 → XP_006527068.1  leucine zipper putative tumor suppressor 2 isoform X3

    See identical proteins and their annotated locations for XP_006527068.1

    Conserved Domains (2) summary
    pfam06818
    Location:220 → 416
    Fez1
    pfam13851
    Location:183 → 255
    GAS; Growth-arrest specific micro-tubule binding

  5. XM_030250900.1 → XP_030106760.1  leucine zipper putative tumor suppressor 2 isoform X2

    Conserved Domains (2) summary
    pfam06818
    Location:304 → 500
    Fez1
    pfam13851
    Location:267 → 339
    GAS; Growth-arrest specific micro-tubule binding
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YU6.3 GenPept UniProtKB/Swiss-Prot:Q91YU6

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