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Pcgf2 polycomb group ring finger 2 [ Mus musculus (house mouse) ]

Gene ID: 22658, updated on 27-Nov-2024

Summary

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Official Symbol
Pcgf2provided by MGI
Official Full Name
polycomb group ring finger 2provided by MGI
Primary source
MGI:MGI:99161
See related
Ensembl:ENSMUSG00000018537 AllianceGenome:MGI:99161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mel18; Rnf110; Zfp144; mel-18
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of transcription by RNA polymerase II. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 21.4), whole brain E14.5 (RPKM 19.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Pcgf2 in Genome Data Viewer
Location:
11 D; 11 61.06 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97579647..97593260, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97688821..97702434, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 Neighboring gene microRNA 6927 Neighboring gene STARR-positive B cell enhancer ABC_E7050 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene STARR-positive B cell enhancer ABC_E7051 Neighboring gene STARR-positive B cell enhancer ABC_E1430 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT) Neighboring gene proteasome (prosome, macropain) subunit, beta type 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Tetsu O, et al. Immunity, 1998 Oct. PMID 9806630
  2. Mel-18 controls the enrichment of tumor-initiating cells in SP fraction in mouse breast cancer. Janakiraman H, et al. Hiroshima J Med Sci, 2011 Jun. PMID 21970185
  3. Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. Tagawa M, et al. J Biol Chem, 1990 Nov 15. PMID 2246278
  4. Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway. Miyazaki M, et al. J Immunol, 2005 Mar 1. PMID 15728456
  5. The mouse Mel-18 "RING-finger" gene: genomic organization, promoter analysis and chromosomal assignment. Asano H, et al. DNA Seq, 1993. PMID 8219280

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BMI1 and MEL18 contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells.
    Title: BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3.
  2. Data indicate that Bmi1 and Mel18 have opposing functions and are present in distinct complexes.
    Title: Regulation of hematopoietic stem cells using protein transduction domain-fused Polycomb.
  3. Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.
    Title: Mel-18 controls the enrichment of tumor-initiating cells in SP fraction in mouse breast cancer.
  4. Data show that Mel-18 and Ezh2 positively regulate the expression of Il17a and Il17f.
    Title: The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines.
  5. observed that expression of the PcG genes-bmi1 and mel-18-is correlated with self-renewal and differentiation of HSCs. Thus, it was suggested that the balance between Bmi1 and Mel-18 regulates self-renewal of HSCs
    Title: Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells.
  6. Sf3b1-Zfp144 protein interaction is essential for true Polycomb group proteins mediated repression of Hox genes.
    Title: Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.
  7. involved in the specification of the anterior-posterior axis in mice
    Title: Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.
  8. Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18
    Title: Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18.
  9. Loss or knockdown of mel-18 leads to the expression of Hoxb4, an increase in the proportion of hematopoietic stem cells in G0 phase, and the subsequent promotion of HSC self-renewal.
    Title: Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells.
  10. Mel-18 contributes to the maintenance of the active state of the Hes-1 gene as a cellular memory system, thereby supporting the expansion of early T lymphocyte progenitors.
    Title: Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables ubiquitin-protein transferase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of PRC1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sex chromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polycomb group RING finger protein 2
Names
DNA-binding protein Mel-18
melanoma nuclear protein 18
ring finger protein 110
zfp-144
zinc finger protein 144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163307.1 → NP_001156779.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_001156779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK142837, BB406926, BI991588, D90085
    Consensus CDS
    CCDS25327.1
    UniProtKB/Swiss-Prot
    P23798
    Related
    ENSMUSP00000137517.2, ENSMUST00000179765.8
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  2. NM_001163308.1 → NP_001156780.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_001156780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK142837, BB406926, D90085
    Consensus CDS
    CCDS25327.1
    UniProtKB/Swiss-Prot
    P23798
    Related
    ENSMUSP00000126967.2, ENSMUST00000169807.8
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  3. NM_009545.2 → NP_033571.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_033571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK142837, BB406926, BB872501, BY008477, D90085
    Consensus CDS
    CCDS25327.1
    UniProtKB/Swiss-Prot
    P23798
    Related
    ENSMUSP00000018681.8, ENSMUST00000018681.14
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97579647..97593260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156633.1 → XP_036012526.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  2. XM_011248975.3 → XP_011247277.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011247277.1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  3. XM_011248972.3 → XP_011247274.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011247274.1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  4. XM_036156632.1 → XP_036012525.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  5. XM_011248973.3 → XP_011247275.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011247275.1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23798.2 GenPept UniProtKB/Swiss-Prot:P23798

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