Lyplal1 lysophospholipase-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyplal1provided by MGI
Official Full Name: lysophospholipase-like 1provided by MGI
Primary source: MGI:MGI:2385115
See related: Ensembl:ENSMUSG00000039246 AllianceGenome:MGI:2385115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Q96AVO
Summary: Predicted to enable carboxylic ester hydrolase activity and palmitoyl-(protein) hydrolase activity. Acts upstream of or within negative regulation of Golgi to plasma membrane protein transport and protein depalmitoylation. Located in cytosol. Is expressed in brain; male reproductive gland or organ; and metanephros. Orthologous to human LYPLAL1 (lysophospholipase like 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in kidney adult (RPKM 40.2), genital fat pad adult (RPKM 18.5) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H5; 1 89.81 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (185819929..185849507, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (186087732..186117310, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity.
Title: Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity.
Lyplal1 mRNA was up-regulated during adipogenesis and enriched in mature adipocytes through a PPARgamma-independent mechanism. overexpression and knockdown of Lyplal1 did not perturb adipogenesis, triacylglycerol accumulation and/or insulin signaling.
Title: Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity, acting on ester bonds	ISO Inferred from Sequence Orthology more info
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-(protein) hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in macromolecule depalmitoylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGAS/STING signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein depalmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophospholipase-like protein 1

NP_666218.2

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146106.2 → NP_666218.2 lysophospholipase-like protein 1

Status: VALIDATED

Source sequence(s)

AC121970, AK148533

Consensus CDS

CCDS15600.1

UniProtKB/Swiss-Prot

Q3UFF7, Q8R065

UniProtKB/TrEMBL

E9QLB2

Related

ENSMUSP00000048229.8, ENSMUST00000045388.8

Conserved Domains (1) summary

cl21494
Location:14 → 226

Abhydrolase; alpha/beta hydrolases