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Zbtb7b zinc finger and BTB domain containing 7B [ Mus musculus (house mouse) ]

Gene ID: 22724, updated on 27-Nov-2024

Summary

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Official Symbol
Zbtb7bprovided by MGI
Official Full Name
zinc finger and BTB domain containing 7Bprovided by MGI
Primary source
MGI:MGI:102755
See related
Ensembl:ENSMUSG00000028042 AllianceGenome:MGI:102755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thpok; Zfp67; c-Krox
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of signal transduction; regulation of alpha-beta T cell activation; and regulation of gene expression. Acts upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; early conceptus; forebrain; genitourinary system; and sensory organ. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 66.4), duodenum adult (RPKM 59.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb7b in Genome Data Viewer
Location:
3 F1; 3 39.09 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89284953..89300976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89377644..89393673, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene STARR-positive B cell enhancer ABC_E4553 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_08235 Neighboring gene STARR-seq mESC enhancer starr_08237 Neighboring gene STARR-positive B cell enhancer ABC_E3446 Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes. Liu X, et al. J Immunol, 2005 Oct 1. PMID 16177089
  2. The CD4/CD8 lineages: central decisions and peripheral modifications for T lymphocytes. Tanaka H, et al. Curr Top Microbiol Immunol, 2014. PMID 23612990
  3. ThPOK derepression is required for robust CD8 T cell responses to viral infection. Setoguchi R, et al. J Immunol, 2009 Oct 1. PMID 19734230, Free PMC Article
  4. CD4 CTL: living up to the challenge. Cheroutre H, et al. Semin Immunol, 2013 Nov 15. PMID 24246226, Free PMC Article
  5. Views on helper/cytotoxic lineage choice from a bottom-up approach. Taniuchi I. Immunol Rev, 2016 May. PMID 27088909

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function.
    Title: ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function.
  2. ThPOK is a critical multifaceted regulator of myeloid lineage development.
    Title: ThPOK is a critical multifaceted regulator of myeloid lineage development.
  3. The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection.
    Title: The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection.
  4. Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis.
    Title: Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis.
  5. Twist2 promotes CD8(+) T-cell differentiation by repressing ThPOK expression.
    Title: Twist2 promotes CD8(+) T-cell differentiation by repressing ThPOK expression.
  6. Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
    Title: Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
  7. Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4(+) T cell identity and function.
    Title: Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4(+) T cell identity and function.
  8. A Fateful Decision in the Thymus Controlled by the Transcription Factor ThPOK.
    Title: A Fateful Decision in the Thymus Controlled by the Transcription Factor ThPOK.
  9. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.
    Title: Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.
  10. Identified an R367Q mutation in the ZBTB7B (ThPOK) protein.
    Title: ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Spontaneous (1)  1 citation
  • Targeted (18)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC102577

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adaptive thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lactation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of NK T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of T-helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to insulin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 7B
Names
T-helper-inducing POZ/Krueppel-like factor
Vzinc finger and BTB domain containing 7B
krueppel-related zinc finger protein cKrox
zinc finger protein 67
zinc finger protein Th-POK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355206.2 → NP_001342135.2  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
    Related
    ENSMUSP00000103058.2, ENSMUST00000107435.8

  2. NM_001355211.2 → NP_001342140.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17504.1
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
    Related
    ENSMUSP00000103055.2, ENSMUST00000107432.8
    Conserved Domains (4) summary
    COG5048
    Location:349 → 428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9 → 142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420 → 445
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001355212.2 → NP_001342141.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17504.1
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
    Related
    ENSMUSP00000103056.2, ENSMUST00000107433.8
    Conserved Domains (4) summary
    COG5048
    Location:349 → 428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9 → 142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420 → 445
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001410678.1 → NP_001397607.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24

  5. NM_001410679.1 → NP_001397608.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24

  6. NM_001410680.1 → NP_001397609.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24

  7. NM_001410681.1 → NP_001397610.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24

  8. NM_009565.6 → NP_033591.2  zinc finger and BTB domain-containing protein 7B

    See identical proteins and their annotated locations for NP_033591.2

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17504.1
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
    Related
    ENSMUSP00000029677.9, ENSMUST00000029677.9
    Conserved Domains (4) summary
    COG5048
    Location:349 → 428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9 → 142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420 → 445
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89284953..89300976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64321.2 GenPept UniProtKB/Swiss-Prot:Q64321

Gene LinkOut

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Chemical Information
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