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B3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 [ Mus musculus (house mouse) ]

Gene ID: 227327, updated on 27-Nov-2024

Summary

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Official Symbol
B3gnt7provided by MGI
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7provided by MGI
Primary source
MGI:MGI:2384394
See related
Ensembl:ENSMUSG00000079445 AllianceGenome:MGI:2384394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
beta-3GnT7; C330001H22Rik
Summary
Predicted to enable acetylglucosaminyltransferase activity. Involved in keratan sulfate biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human B3GNT7 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 350.5), large intestine adult (RPKM 52.5) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See B3gnt7 in Genome Data Viewer
Location:
1 C5; 1 43.94 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86230943..86235027)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86303221..86307305)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 9 Neighboring gene STARR-positive B cell enhancer mm9_chr1:88154834-88155134 Neighboring gene predicted gene, 46098 Neighboring gene predicted gene 16341 Neighboring gene CRISPRi-validated B3gnt7 cis-regulatory element Neighboring gene predicted gene 28626 Neighboring gene predicted gene 5258 Neighboring gene STARR-seq mESC enhancer starr_01572 Neighboring gene small nucleolar RNA, H/ACA box 75 Neighboring gene nucleolin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Keratan Sulfate Phenotype in the β-1,3-N-Acetylglucosaminyltransferase-7-Null Mouse Cornea. Littlechild SL, et al. Invest Ophthalmol Vis Sci, 2018 Mar 1. PMID 29625490, Free PMC Article
  2. B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation. Wang T, et al. BMC Gastroenterol, 2024 Jun 17. PMID 38886669, Free PMC Article
  3. A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro. Kataoka K, et al. Biochem Biophys Res Commun, 2002 Jun 21. PMID 12061784
  4. Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. de Ledesma AM, et al. Mamm Genome, 2006 Feb. PMID 16465591
  5. Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors. Cunningham TJ, et al. Biol Open, 2016 Dec 15. PMID 27793834, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation.
    Title: B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation.
  2. beta3GnT7 may play a role in preventing cells from migrating out of the original tissues
    Title: A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in keratan sulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in keratan sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in keratan sulfate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Names
BGnT-7
beta-1,3-Gn-T7
beta-1,3-N-acetylglucosaminyltransferase 7
beta3Gn-T7
NP_660257.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145222.2 → NP_660257.2  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

    See identical proteins and their annotated locations for NP_660257.2

    Status: VALIDATED

    Source sequence(s)
    AK131975, AV456413, BB591167, BX521960
    Consensus CDS
    CCDS35645.1
    UniProtKB/Swiss-Prot
    Q3U3L9, Q3V283, Q6PA02, Q8BJS5, Q8K0J2, Q8K437
    Related
    ENSMUSP00000108931.3, ENSMUST00000113306.4
    Conserved Domains (1) summary
    cl21608
    Location:144 → 338
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    86230943..86235027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0J2.2 GenPept UniProtKB/Swiss-Prot:Q8K0J2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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