U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfr zinc finger RNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 22763, updated on 27-Nov-2024

Summary

Official Symbol
Zfrprovided by MGI
Official Full Name
zinc finger RNA binding proteinprovided by MGI
Primary source
MGI:MGI:1341890
See related
Ensembl:ENSMUSG00000022201 AllianceGenome:MGI:1341890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C920030H05Rik
Summary
Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Predicted to be located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; submandibular gland primordium; and vibrissa. Orthologous to human ZFR (zinc finger RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 32.5), cortex adult (RPKM 29.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Zfr in Genome Data Viewer
Location:
15 A1; 15 5.9 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (12117649..12185535)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (12117563..12185449)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38007 Neighboring gene predicted gene 2559 Neighboring gene predicted gene, 34759 Neighboring gene microRNA 1898 Neighboring gene predicted gene 2573 Neighboring gene STARR-positive B cell enhancer ABC_E2438 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene myotubularin related protein 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12160369-12160618

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC176100

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger RNA-binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358823.1NP_001345752.1  zinc finger RNA-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC161269
    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (3) summary
    smart00572
    Location:720974
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:517548
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:520542
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_011767.2NP_035897.2  zinc finger RNA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_035897.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF071059, AK034963, AK041429, BC058570, BU757317
    Consensus CDS
    CCDS37044.2
    UniProtKB/Swiss-Prot
    O88532, Q3TY30, Q8BS85, Q8CGG5, Q91VZ0, Q9CT34
    UniProtKB/TrEMBL
    B2RUG7
    Related
    ENSMUSP00000118911.2, ENSMUST00000122941.8
    Conserved Domains (4) summary
    smart00572
    Location:7841038
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:382551
    PHA03255; BDLF3; Provisional
    smart00451
    Location:581612
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:584606
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    12117649..12185535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520057.2XP_006520120.1  zinc finger RNA-binding protein isoform X1

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:7921046
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:390559
    PHA03255; BDLF3; Provisional
    smart00451
    Location:589620
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:341363
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006520059.3XP_006520122.1  zinc finger RNA-binding protein isoform X5

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (3) summary
    smart00572
    Location:728982
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:525556
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:528550
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_030248530.1XP_030104390.1  zinc finger RNA-binding protein isoform X3

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:7721026
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:370539
    PHA03255; BDLF3; Provisional
    smart00451
    Location:569600
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:321343
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_036159388.1XP_036015281.1  zinc finger RNA-binding protein isoform X6

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (3) summary
    smart00572
    Location:708962
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:505536
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:508530
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_006520058.4XP_006520121.1  zinc finger RNA-binding protein isoform X2

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:7801034
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:378547
    PHA03255; BDLF3; Provisional
    smart00451
    Location:577608
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:329351
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_017316588.1XP_017172077.1  zinc finger RNA-binding protein isoform X4

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:740994
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:338507
    PHA03255; BDLF3; Provisional
    smart00451
    Location:537568
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_001781521.2 RNA Sequence

  2. XR_001781520.3 RNA Sequence

  3. XR_001781522.3 RNA Sequence