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Sec16a SEC16 homolog A, endoplasmic reticulum export factor [ Mus musculus (house mouse) ]

Gene ID: 227648, updated on 27-Nov-2024

Summary

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Official Symbol
Sec16aprovided by MGI
Official Full Name
SEC16 homolog A, endoplasmic reticulum export factorprovided by MGI
Primary source
MGI:MGI:2139207
See related
Ensembl:ENSMUSG00000026924 AllianceGenome:MGI:2139207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p250; C230052J16Rik
Summary
Involved in endoplasmic reticulum organization; protein exit from endoplasmic reticulum; and protein localization to plasma membrane. Located in endoplasmic reticulum exit site and perinuclear region of cytoplasm. Is expressed in cerebral cortex. Orthologous to human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 22.5), ovary adult (RPKM 20.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sec16a in Genome Data Viewer
Location:
2 A3; 2 18.89 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26299443..26336138, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26409431..26446293, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endosome associated trafficking regulator 1 Neighboring gene peptidase (mitochondrial processing) alpha Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene STARR-positive B cell enhancer ABC_E5900 Neighboring gene RIKEN cDNA 0610009E02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1241 Neighboring gene STARR-seq mESC enhancer starr_03982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26316530-26316713 Neighboring gene notch 1 Neighboring gene microRNA 6996 Neighboring gene STARR-positive B cell enhancer ABC_E2031 Neighboring gene predicted gene, 35978

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress. Wang MJ, et al. Adv Sci (Weinh), 2024 Oct. PMID 39119875, Free PMC Article
  2. Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum. Iinuma T, et al. J Biol Chem, 2007 Jun 15. PMID 17428803
  3. Nbeal2 interacts with Dock7, Sec16a, and Vac14. Mayer L, et al. Blood, 2018 Mar 1. PMID 29187380, Free PMC Article
  4. SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. Bruno J, et al. J Cell Biol, 2016 Jul 4. PMID 27354378, Free PMC Article
  5. Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. Cho HJ, et al. EMBO J, 2014 Oct 16. PMID 25201882, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.
    Title: SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.
  2. SEC16A and RAB10 promote insulin-stimulated mobilization of GLUT4 from a perinuclear recycling endosome/trans Golgi network compartment.
    Title: SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38812

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to plasma membrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of COPII vesicle coating IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein transport protein Sec16A
NP_694765.2
XP_006497973.2
XP_006497974.1
XP_006497976.1
XP_011237375.1
XP_030105628.2
XP_036016658.1
XP_036016660.1
XP_036016666.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153125.2 → NP_694765.2  protein transport protein Sec16A

    Status: VALIDATED

    Source sequence(s)
    AA388295, AI851539, AK122242, AK162931, BC034649, BF456838, BQ950511, BU704044, CA463107, CJ098463, CK638146, CO432077, CV883992, CX236472
    Consensus CDS
    CCDS38085.1
    UniProtKB/Swiss-Prot
    A2AIX1, E9QAT4, Q80U43, Q811L5
    Related
    ENSMUSP00000088796.5, ENSMUST00000091252.5
    Conserved Domains (4) summary
    cd09233
    Location:1512 → 1874
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    pfam10697
    Location:1270 → 1332
    DUF2502; Protein of unknown function (DUF2502)
    cl25764
    Location:58 → 285
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:669 → 1241
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26299443..26336138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497910.5 → XP_006497973.2  protein transport protein Sec16A isoform X1

    Conserved Domains (2) summary
    cd09233
    Location:1512 → 1874
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:2 → 291
    PHA03247; large tegument protein UL36; Provisional

  2. XM_030249768.2 → XP_030105628.2  protein transport protein Sec16A isoform X1

    Conserved Domains (2) summary
    cd09233
    Location:1512 → 1874
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:2 → 291
    PHA03247; large tegument protein UL36; Provisional

  3. XM_011239073.3 → XP_011237375.1  protein transport protein Sec16A isoform X6

    Conserved Domains (4) summary
    cd09233
    Location:1280 → 1642
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:667 → 1009
    PHA03247; large tegument protein UL36; Provisional
    pfam09770
    Location:58 → 285
    PAT1; Topoisomerase II-associated protein PAT1
    pfam10697
    Location:1038 → 1100
    DUF2502; Protein of unknown function (DUF2502)

  4. XM_036160773.1 → XP_036016666.1  protein transport protein Sec16A isoform X5

    Conserved Domains (2) summary
    cd09233
    Location:1280 → 1642
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:2 → 291
    PHA03247; large tegument protein UL36; Provisional

  5. XM_006497913.4 → XP_006497976.1  protein transport protein Sec16A isoform X4

    Conserved Domains (4) summary
    cd09233
    Location:1512 → 1874
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:669 → 1241
    PHA03247; large tegument protein UL36; Provisional
    pfam09770
    Location:58 → 285
    PAT1; Topoisomerase II-associated protein PAT1
    pfam10697
    Location:1270 → 1332
    DUF2502; Protein of unknown function (DUF2502)

  6. XM_036160767.1 → XP_036016660.1  protein transport protein Sec16A isoform X2

    Conserved Domains (2) summary
    cd09233
    Location:1512 → 1874
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:2 → 291
    PHA03247; large tegument protein UL36; Provisional

  7. XM_006497911.4 → XP_006497974.1  protein transport protein Sec16A isoform X3

    UniProtKB/TrEMBL
    A2AIX1
    Related
    ENSMUSP00000109716.3, ENSMUST00000114082.9
    Conserved Domains (4) summary
    cd09233
    Location:1512 → 1874
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:669 → 1241
    PHA03247; large tegument protein UL36; Provisional
    pfam09770
    Location:58 → 285
    PAT1; Topoisomerase II-associated protein PAT1
    pfam10697
    Location:1270 → 1332
    DUF2502; Protein of unknown function (DUF2502)

  8. XM_036160765.1 → XP_036016658.1  protein transport protein Sec16A isoform X1

    Conserved Domains (2) summary
    cd09233
    Location:1512 → 1874
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:2 → 291
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9QAT4.1 GenPept UniProtKB/Swiss-Prot:E9QAT4

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